Maria Raffaella Zocchi


Email: zocchi.maria@hsr.it
Location: Sector L, Floor 1s, Room 4

Group leader, Gammadelta T lymphocytes in innate and acquired immunity Unit

The PI has been working on cellular and tumor immunology for more than 25 years, on AIRC funded projects, focusing on:

  • γδ T cell recognition and function in immune diseases (SLE, Multiple Sclerosis, AIDS) and hematologic malignancies. (PMID: 15604289; PMID: 16973957; doi: 10.1182/blood-2009-01-198028;, doi/10.1371/annotation/1ada33bd-76c7-4b66-906f-950b383111e8.; doi: 10.1080/2162402X.2016.1278099.
  • Mechanisms of signal transduction upon interaction between leukocytes and endothelium or subendothelial matrix. (PMID: 9774384; PMID: 10201968; PMID: 10623814; PMID: 12055216; PMID: 12393747; PMID: 14630801)
  • Production and characterizaztion of anti-CD31 (clone M89D3) and anti integrin-α1 (clone FB12) monoclonal antibodies recognizing adhesion molecules involved in leucocyte-endothelial interactions and leukemic cell growth. These mAbs have been licensed. (PMID: 8864174; PMID: 8625965; PMID: 8764109; PMID: 9774384; PMID: 12393747; doi: 10.1111/j.1365-2141.2010.08343.x)
  • Generation of regulatory T lymphocytes by mesenchymal stromal cells in Hodgkin/non-Hodgkin lymphomas. (doi: 10.1182/blood-2011-07-370841; doi: 10.3324/haematol.2013.097311)
  • Development and characterization of two new ADAM10 specific inhibitors (e1123367. doi: 10.1080/ 2162402X.2015.1123367; doi: 10.1016/j.ejmech. 2016.01.053.) and conjugation with fluorescent probes and gold particles for cell imaging, immunohistochemistry and electron microscopy (OncoImmunol. submitted; Bioconjugate Chem. submitted).