Immunology, Transplantation and Infectious diseases
Immuno-hematology and transfusion medicine
IRCCS Ospedale San Raffaele Immunohematology and Transfusion Medicine Service (ITMS) provides clinical services to support patients in need of blood component therapy, cellular therapy, therapeutic apheresis and specialized laboratory diagnostics. Working in tandem with ITMS, the Immune-hematology and transfusion medicine Unit carries out research projects addressing the improvement of clinics and diagnostic tools in the area of transfusion medicine.
Research activity
Research activities applied to clinics:
- Blood components for non-transfusion use (application in dermatology, orthopedics, ophthalmology), with special regard for regenerative medicine.
- Patient blood management, especially in routine and emergency surgery and trauma/intensive care.
- Identification of blood components for specific patient categories, such as newborns and infants.
- Cryopreservation of blood components
Research activities applied to diagnostics:
- Collaboration with Hematology and Bone Marrow Transplantation Unit research group in molecular diagnostics applied to the management of patients undergoing allogeneic SCT, especially for the detection of minimal residual disease and early relapse.
- Collaboration with Hematology and bone Marrow Transplantation Unit research group in molecular diagnostics applied to the management of patients with hematologic malignancies.
- Flow-cytometry and molecular diagnostic for optimizing diagnostic and follow- up of patients with hematologic diseases: collaboration with REL (Rete Ematologica Lombarda), European Leukemia Net and several other groups.
Tassara M, De Ponti A, Barzizza L, Zambelli M, Parisi C, Milani R, Santoleri L. Autologous conditioned serum (ACS) for intra- articular treatment in Osteoarthritis: Retrospective report of 28 cases. Transfus Apher Sci. 2018 Aug;57(4):573-577.
Gelibter S, Mazzi B, Tassara M, Colombo B, Guerrieri S, Giordano A, Preziosa P, Comola M, Esposito F, Martinelli V, Rocca MA, Comi G, Leocani L, Martinelli Boneschi F. Neuromyelitis optica spectrum disorder and multiple sclerosis in a Sardinian family. Mult Scler Relat Disord. 2018 Oct; 25:73 - 76.
Crocchiolo R, Ringden O, Bay JO, Blaise D, Omasic B , Mazzi B, Picard C, Trinca S, Ba k holt L, Peccatori J, Gregori S, Amodio G, Fleischhauer K, Ciceri F, Bregni M. Impact of HLA-G polymorphism on the outcome of allogeneic hematopoietic st em cell transplantation for metastatic renal cell carcinoma. Bone Marrow Transplant. 2018 Feb;53(2):213-218.
Agathangelidis A, Sutton LA, Hadzidimitriou A, Tresoldi C, Langerak AW, Belessi C, Davi F, Rosenquist R, Stamatopoulos K, Ghia P. Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation. J Vis Exp. 2018 Nov 26;(141).
Lanzillotta M, Della-Torre E, Milani R, Bozzolo E, Bozzalla-Cassione E, Rovati L, Arcidiacono PG, Partelli S, Falconi M, Ciceri F, Dagna L. Increase of circulating memory B cells after glucocorticoid-induced remission identifies patients at risk of IgG4-related disease relapse. Arthritis Res Ther. 2018 Oct 3;20(1):222.
Trojani A, Pungolino E, Rossi G, D'Adda M, Lodola M, Camillo BD, Perego A, Turrini M, Orlandi E, Borin L, Iurlo A, Malato S, Spina F, Latargia ML, Lanza F, Artale S, Anghilieri M, Carraro MC, Canal G, Morra E, Cairoli R. Wide-transcriptome analysis and cellularity of bone marrow CD34+/lin- cells of patients with chronic-phase chronic myeloid leukemia at diagnosis vs. 12 months of first-line nilotinib treatment. Cancer Biomark. 2017 Dec 12;21(1):41-53.
Ingo DM, Redaelli D, Rossella V, Perini O, Santoleri L, Ciceri F, Aiuti A, Bernardo ME. Bone marrow-derived CD34- fraction: A rich source of mesenchymal stromal cells for clinical application. Cytotherapy 2016 Dec;18(12):1560-1563.
Della Porta MG, Gallì A, Bacigalupo A, Zibellini S, Bernardi M, Rizzo E, Allione B, van Lint MT, Pioltelli P, Marenco P, Bosi A, Voso MT, Sica S, Cuzzola M, Angelucci E, Rossi M, Ubezio M, Malovini A, Limongelli I, Ferretti VV, Spinelli O, Tresoldi C, Pozzi S, Luchetti S, Pezzetti L, Catricalà S, Milanesi C, Riva A, Bruno B, Ciceri F, Bonifazi F, Bellazzi R, Papaemmanuil E, Santoro A, Alessandrino EP, Rambaldi A, Mario Cazzola M. Clinical effects of driver somatic mutations on the outcomes of patients with myelodysplastic syndromes treated with allogeneic hematopoietic stem cell transplantation. J Clin Oncol. 2016 Sep 6. pii: JCO673616.
De Freitas T, Marktel S, Piemontese S, Carrabba MG, Tresoldi C, Messina C, Lupo Stanghellini MT, Assanelli A, Corti C, Bernardi M, Peccatori J, Vago L, Ciceri F, Migliavacca J, Percio S, Valsecchi R, Ferrero E, Spinelli A, Ponzoni M, Tresoldi C, Pattini L, Bernardi R, Coltella N. High rate of hematological responses to sorafenib in FLT3-ITD acute myeloid leukemia relapsed after allogeneic hematopoietic stem cell transplantation. Eur J Haematol. 2016 Jun; 96(6) 629-36.
Brambati C, Galbiati S, Xue E, Toffalori C, Crucitti L, Greco R, Sala E, Crippa A, Chiesa L, Soriani N, Mazzi B, Tresoldi C, Stanghellini MT, Peccatori J, Carrabba MG, Bernardi M, Ferrari M, Lampasona V, Ciceri F, Vago L. Droplet digital polymerase chain reaction for DNMT3A and IDH1/2 mutations to improve early detection of acute myeloid leukemia relapse after allogeneic hematopoietic stem cell transplantation. Haematologica 2016 Apr;101(4):e157-61.
Xue E, Tresoldi C, Sala E, Crippa A, Mazzi B, Greco R, Messina C, Carrabba MG, Lupo Stanghellini MT, Marktel S, Corti C, Peccatori J, Bernardi M, Ciceri F, Vago L. Longitudinal qPCR monitoring of nucleophosmin 1 mutations after allogeneic hematopoietic stem cell transplantation to predict AML relapse. Bone Marrow Transplant. 2016 Mar;51(3):466-9.
Bertani G, Santoleri L, Ferri U, Marenco P, Grillo G, Zucchetti E, Forno B, Lando G, Scarpati B, Cairoli R, Rossini S, Cesana C. Response of steroid-refractory chronic graft-versus-host disease to extracorporeal photopheresis correlates with the dose of CD3+ lymphocytes harvested during early treatment cycles. Transfusion 2016 Feb;56(2):505-10.
Bertani G, Santoleri L, Martino M, Fedele R, Moscato T, Marenco P, Grillo G, Zucchetti E, Lotesoriere I, Lando G, Cesana C, Cairoli R, Rossini S. Identification of hematopoietic progenitor cell donor characteristics predicting successful mobilization: results of an Italian multicenter study. Transfusion 2014 Aug;54(8):2028-33.
Coluccia P, Crovetti G, Del Fante C, Dallavalle FM, Laszlò D, Ferremi P, Marenchino D, Santoleri L, De Filippo C, Mattana F, Mariani L, Perseghin P, Ravagnani F. Screening of related donors and peripheral blood stem cell collection practices at different Italian apheresis centres. Blood Transfus. 2012 Oct;10(4):440-7.
Cinzia Bargiggia
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Ilaria Ambaglio
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Laura Bellio
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Alketa Boletini
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Aurelio Caldarola
Biologist
Annika Calloni
Biologist
Milena Coppola
Physician
Gianfranco Deodato
Biologist
Salvatore Gattillo
Physician
Maria Antonia Introini
Biologist
Lucia Malabarba
Physician
Simona Malato
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Benedetta Mazzi
Chemist
Raffaella Milani
Physician
Oriana Perini
Biologist
Paola Ronchi
Physician
Michela Tassara
Physician
Cristina Tresoldi
Biologist
Stefano Zangrossi
Biologist