In vivo structural and molecular neuroimaging
The research projects of the Unit include molecular neuroimaging with PET, structural and functional neuroimaging with MRI with the aim to investigate in vivo the pathophysiology of neurological diseases and the neural correlates of cognitive functions in the norm and in pathology. This is a complex research field allowing the measurement of functional and biochemical brain processes such as glucose metabolism, neurotransmission systems, the burden of pathology as amyloid and tau protein, and neuroinflammation.
The use of these techniques provide crucial evidence for brain plasticity and reserve, for the effects of brain aging and, particularly for the molecular PET imaging, supportive features for the early and differential diagnosis in the diagnostic criteria of neurodegenerative dementias. The research Unit is part of several national and international multicentric projects and of European Networks of Excellence.
Tettamanti M, Conca F, Falini A, Perani D. Unaware processing of tools in the neural system for object-directed action representation. J Neurosci. 2017 Oct 4. pii: 1061-17.
Iaccarino L, Chiotis K, Alongi P, Almkvist O, Wall A, Cerami C, Bettinardi V, Gianolli L, Nordberg A, Perani D.A. Cross-validation of FDG- and amyloid-PET biomarkers in mild cognitive impairment for the risk prediction to dementia due to Alzheimer's disease in a clinical setting. J Alzheimers Dis. 2017;59(2):603- 614.
Malpetti M, Ballarini T, Presotto L, Garibotto V, Tettamanti M, Perani D; Disease Neuroimaging Initiative (ADNI) database Network for Efficiency and Standardization of Dementia Diagnosis (NEST-DD). Gender differences in healthy aging and Alzheimer's Dementia: A 18 F-FDG-PET study of brain and cognitive reserve. Alzheimer's Hum Brain Mapp. 2017 Aug;38(8):4212-4227.
Sala A, Caminiti SP, Presotto L, Premi E, Pilotto A, Turrone R, Cosseddu M, Alberici A, Paghera B, Borroni B, Padovani A, Perani D. Altered brain metabolic connectivity at multiscale level in early Parkinson's disease. Sci Rep. 2017 Jun 26;7(1):4256.
Iaccarino L, Moresco RM, Presotto L, Bugiani O, Iannaccone S, Giaccone G, Tagliavini F, Perani D. An in vivo 11C-(R)-PK11195 PET and in vitro pathology study of microglia activation in Creutzfeldt-Jakob Disease. Mol Neurobiol. 2017 Apr 28. doi: 10.1007/s12035-017-0522-6. [Epub ahead of print]
Caminiti SP, Tettamanti M, Sala A, Presotto L, Iannaccone S, Cappa SF, Magnani G, Perani D; Alzheimer’s Disease Neuroimaging Initiative (ADNI). Metabolic connectomics targeting brain pathology in dementia with Lewy bodies. J Cereb Blood Flow Metab. 2017 Apr;37(4):1311-1325.
Caminiti SP, Presotto L, Baroncini D, Garibotto V, Moresco RM, Gianolli L, Volonté MA, Antonini A, Perani D. Axonal damage and loss of connectivity in nigrostriatal and mesolimbic dopamine pathways in early Parkinson's disease. Neuroimage Clin. 2017 Mar 27;14:734-740.
Perani D, Farsad M, Ballarini T, Lubian F, Malpetti M, Fracchetti A, Magnani G, March A, Abutalebi J. The impact of bilingualism on brain reserve and metabolic connectivity in Alzheimer's dementia. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1690-1695.
Ballarini T, Iaccarino L, Magnani G, Ayakta N, Miller BL, Jagust WJ, Gorno- Tempini ML, Rabinovici GD, Perani D. Neuropsychiatric subsyndromes and brain metabolic network dysfunctions in early onset Alzheimer's disease. Hum Brain Mapp. 2016 Dec;37(12):4234-4247.
Cerami C, Dodich A, Lettieri G, Iannaccone S, Magnani G, Marcone A, Gianolli L, Cappa SF, Perani D. Different FDG-PET metabolic patterns at single-subject level in the behavioral variant of fronto-temporal dementia. Cortex 2016 Oct;83:101-12.