Regulation of adaptive immunity

Regulation of adaptive immunity


Group Leader

Georgia Fousteri


Regulation of adaptive immunity studies the mechanisms that control autoimmunity and antiviral immunity. By maintaining the immune system in equilibrium, the body is protected from autoimmune diseases such as type 1 diabetes and from excessive or undesired responses against viruses. More precisely, the group is investigating how PTPN22, a gene associated with autoimmunity, controls virus-specific T cell responses, characterizing the contribution of T follicular helper and regulatory T cells - two T cell subsets that aid and control antibody responses-respectively - in the development of autoimmunity. The research group is also addressing how regulatory T cells control antiviral immunity, and vice versa, how viral infections impede regulatory T cell function and stability. The aim is to aid in the design of efficient and safe tolerogenic approaches to control autoimmunity without compromising host antiviral immune defence.