The Unit is mostly involved in the evaluation of epileptic manifestations, in particular in the study of the electroencephalographic and therapeutic characteristics of Status Epilepticus (SE). Data collection is currently being completed on three relevant clinical aspects.
- The first study is related to the risk of relapse of seizures after suspension of therapy in patients with a good control of seizures for at least 3 years.
- The second one is related to a comparison between detectable alterations in magnetic resonance imaging and EEG pattern in patients with SE. The relation between these two instrumental examinations could be useful in the future to decide which elements should be taken into consideration not only for diagnosis, but also for the therapeutic management of SE.
- The third study, with a data collection that is still under completion, will come on discussing the possibility of replacing valproate. In women taking valproic acid, there are an increasingly risks related to pregnancy. This evidence forced the Italian and European regulators to a strict position concerning the use of drugs in pregnancy age women. The research strategy provided for mandatory treatment modification for all women followed at our Center and the next follow-up for a comparison with previous therapeutic lines.
Recently, has been submitted for publication a study on the global benefits coming from the introduction of a new transmucosal antiepileptic drug (midazolam), for the treatment in emergency of prolonged seizures and SE. This latest research activity is the most recent one and follows previous studies in cooperation with the italian study group on Status epilepticus.
Beghi E, Capovilla G, Franzoni E, Minicucci F, Romeo A, Verrotti A, Vigevano F, Perucca E. Cost-effectiveness of midazolam versus diazepam in prolonged tonic-clonic seizures in children: a pharmacoeconomic approach. Acta Neurol Scand 2018 Jan;137(1):24-28.
Sauer AV, Hernandez RJ, Fumagalli F, Bianchi V, Poliani PL, Dallatomasina C, Riboni E, Politi LS, Tabucchi A, Carlucci F, Casiraghi M, Carriglio N, Cominelli M, Forcellini CA, Barzaghi F, Ferrua F, Minicucci F, Medaglini S, Leocani L, la Marca G, Notarangelo LD, Azzari C, Comi G, Baldoli C, Canale S, Sessa M, D'Adamo P, Aiuti A. Alterations in the brain adenosine metabolism cause behavioral and neurological impairment in ADA-deficient mice and patients. Sci Rep. 2017 Jan 11;7:40136.
Capovilla G, Beccaria F, Beghi E, Minicucci F, Sartori S, Vecchi M. Treatment of convulsive status epilepticus in childhood: recommendations of the Italian League Against Epilepsy. Epilepsia. 2013 Oct;54 Suppl 7:23-34.
Magri L, Cominelli M, Cambiaghi M, Cursi M, Leocani L, Minicucci F, Poliani PL, Galli R. Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models. Dis Model Mech. 2013 Sep;6(5):1185-97.
Cambiaghi M, Cursi M, Magri L, Castoldi V, Comi G, Minicucci F, Galli R, Leocani L. Behavioural and EEG effects of chronic rapamycin treatment in a mouse model of tuberous sclerosis complex. Neuropharmacology. 2013 Apr;67:1-7.
Cambiaghi M, Cursi M, Monzani E, Benfenati F, Comi G, Minicucci F, Valtorta F, Leocani L. Temporal evolution of neurophysiological and behavioral features of synapsin I/II/III triple knock-out mice. Epilepsy Res. 2013 Feb;103 (2-3):153-60.
Caso F, Cursi M, Magnani G, Fanelli G, Falautano M, Comi G, Leocani L, Minicucci F. Quantitative EEG and LORETA: valuable tools in discerning FTD from AD? Neurobiol Aging. 2012 Oct;33(10):2343-56.
Magri L, Cambiaghi M, Cominelli M, Alfaro-Cervello C, Cursi M, Pala M, Bulfone A, Garcìa-Verdugo JM, Leocani L, Minicucci F, Poliani PL, Galli R. Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions. Cell Stem Cell. 2011 Nov 4;9(5):447-62.
Caso F, Fiorino A, Falautano M, Leocani L, Martinelli V, Minicucci F, Falini A, Comi G, Magnani G. Treatment of Wernicke's encephalopathy with high dose of thiamine in a patient with pyloric sub-stenosis: description of a case. Neurol Sci. 2010 Dec;31(6):859-61.
Noè A, Cappelli B, Biffi A, Chiesa R, Frugnoli I, Biral E, Finizio V, Baldoli C, Vezzulli P, Minicucci F, Fanelli G, Fiori R, Ciceri F, Roncarolo MG, Marktel S. High incidence of severe cyclosporine neurotoxicity in children affected by haemoglobinopaties undergoing myeloablative haematopoietic stem cell transplantation: early diagnosis and prompt intervention ameliorates neurological outcome. Ital J Pediatr. 2010 Feb 6;36:14.