Genomics of the innate immune system

Renato Ostuni

Renato Ostuni

Email: ostuni.renato@hsr.it
Location: DIBIT1 C1, Floor 1, Room 10a

Group leader, Genomics of the innate immune system Unit
Grantee, ERC starting grant

Renato Ostuni obtained a PhD in Immunology in the lab of Francesca Granucci and Ivan Zanoni at the University of Milano-Bicocca. Here, he contributed to discovery of CD14 as a key regulator of biochemical and cell biological responses of inflammatory cells to the bacterial molecule LPS (Nature 2009, Cell 2011, JCI 2012). He did postdoctoral work at the European Institute of Oncology (IEO) with Gioacchino Natoli. Here, he discovered latent enhancers, a class of regulatory elements controlling short-term transcriptional and epigenetic immune memory in activated macrophages (Cell 2013). Since 2015, he is Group Leader at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), where he directs a team of >8 people working on the genomic control of macrophage activation (Nature Immunology, 2017) and on the development of the innate immune system in humans.

Renato Ostuni has published >20 articles in peer-reviewed journals, including papers as first/last author in Cell, Nature and Nature Immunology. Overall, his work has been cited > 1,500 times, with an H-index of 14 and IF > 250.

He has received several prizes and awards, including an ERC Starting Grant in 2017. He is actively involved in public outreach and research dissemination projects with the Telethon Foundation and the Museum of Science and Technology in Milan. His research activity is supported by the Telethon Foundation, the EU (ERC and ERA-NET) and the Cariplo Foundation.