Senescence in stem cell aging, differentiation and cancer

Raffaella Di Micco

Raffaella Di Micco

Email: dimicco.raffaella@hsr.it
Location: DIBIT1 C1, Floor 1, Room 5a

Group leader, Senescence in stem cell aging, differentiation and cancer Unit

The molecular mechanisms of cellular aging and differentiation, so the field of stem cell and cancer biology have always been my main area of interest and fascination. I have worked on several different aspects of this incredibly broad field. During my PhD training at the European School of Molecular Medicine in Fabrizio d’adda di Fagagna lab at IFOM, Milan I investigated the molecular mechanisms by which oncogenes induce DNA damage and cellular senescence. I also focused on the study of alterations of chromatin structure in cancer and on new targeted therapies aimed to re-establish normal epigenetic patterns for cancer treatment. In my postdoctoral training in the lab of Eva Hernando at New York University by using genetic and chemical-based approaches, I identified novel molecular targets involved in the maintenance of stem cell self-renewal capacity, with a particular focus on the epigenetic and transcriptional mechanisms controlling stem cell biology and differentiation in physiological and pathological conditions. During my training in US I was awarded prestigious postdoctoral fellowships including an EMBO long-term fellowship, Human Frontier Science Program (HFSP) and a New York Stem Cell Foundation Druckenmiller fellowship (NYSCF).In the fall 2015 I returned to Italy and at the beginning of 2016 I started the activities of my lab at the San Raffaele Telethon Institute for Gene Therapy.