Myocardial diseases and atherosclerosis
The research activities of the group are focused on identifying mechanisms of cardiovascular impairment and specic therapeutic targets. Myocardial ischemia and occlusion/thrombosis of atherosclerotic arteries (leading cause of angina, acute myocardial infarction and stroke) are interconnected.
Our main research activities are:
- In myocardial diseases the role played by cardiac microvessels is assuming increasing importance. Abnormal functional and structural remodelling of coronary arterioles, detectable by coronary ow reserve measurement and by positron emission tomography (PET) imaging, is a major cause of coronary microvascular dysfunction (CMD) in both primary and secondary cardiomyopathies (e.g. hypertrophic and hypertensive cardiomyopathy, respectively) and CMD is an important determinant of long term prognosis. The mechanisms responsible for CMD remain incompletely understood. However, given their close proximity, microvessels and cardiomyocytes might reciprocally in uence themselves. The Unit is performing clinical and experimental studies to unravel causal/bio-molecular mechanisms at the base of microvascular remodelling and of cardiomyocytes alterations in cardiomyopathies. These investigations involve the determination of expressed genes and microRNAs.
- Arterial microvessels density and features of carotid artery vulnerability are associated. Plaque destabilization involves rupture and exposure to blood ow of thrombogenic or pro/anti-in ammatory vascular components. The activities by the Unit include translational research on the role of extra- cardiac microvasculature in arterial disease and on the atherosclerotic plaque progression. In vivo imaging analyses of the microvascular network and bio-molecular studies exploiting new technologies applied to human vessel samples are performed to unravel the mechanisms of atherosclerotic plaque destabilization and vessel thrombogenicity.
Kaski JC, Crea F, Gersh BJ and Camici PG: Reappraisal of Ischemic Heart Disease - The fundamental role of coronary microvascular dysfunction in the pathogenesis of angina pectoris. Circulation 2018;1381463–1480.
Ammirati E, Cipriani M, Moro C, Raineri C, Pini D, Sormani P, Mantovani R, Varrenti M, Pedrotti P, Conca C, Mafrici A, Grosu A, Briguglia D, Guglielmetto S, Battista Perego G, Colombo S, Caico SI, Giannattasio C, Maestroni A, Carubelli V, Metra M, Lombardi C, Campodonico J, Agostoni P, Peretto G, Scelsi L, Turco A, DiTano G, Campana C, Belloni A, Morandi F, Mortara A, Cirò A, Senni M, Gavazzi A, Frigerio M, Oliva F, Camici PG; Registro Lombardo delle Miocarditi. Clinical Presentation and Outcome in a Contemporary Cohort of Patients with Acute Myocarditis: The Multicenter Lombardy Registry. Circulation. 2018 May 15.
Gupta A, Taqueti VR, van de Hoef TP, Bajaj NS, Bravo PE, Murthy VL, Osborne MT, Seidelmann SB, Vita TS, Bibbo CF, Harrington M, Hainer J, Rimoldi O, Dorbala S, Bhatt DL, Blankstein R, Camici PG, Di Carli MF. Integrated Non-invasive Physiological Assessment of Coronary Circulatory Function and Impact on Cardiovascular Mortality in Patients with Stable Coronary Artery Disease. Circulation. 2017 Sep 1.
Pelliccia F, Kaski JC, Crea F and Camici PG: Pathophysiology of Takotsubo Syndrome. Circulation. 2017 Jun 13;135(24):2426-2441.
Brambatti M, Matassini MV, Adler ED, Klingel K, Camici PG, Ammirati E. Eosinophilic Myocarditis: Characteristics, Treatment, and Outcomes. J Am Coll Cardiol. 2017 Nov 7;70(19):2363-2375.
Ammirati E, Cipriani M, Lilliu M, Sormani P, Varrenti M, Raineri C, Petrella D, Garascia A, Pedrotti P, Roghi A, Bonacina E, Moreo A, Bottiroli M, Gagliardone MP, Mondino MG, Ghio S, Totaro R, Turazza FM, Russo CF, Oliva F, Camici PG, Frigerio M. Survival and Left Ventricular Function Changes in Fulminant Versus Non-Fulminant Acute Myocarditis. Circulation. 2017 Aug 8;136(6):529-545.
Camici PG, d’Amati G, Rimoldi O: Coronary microvascular dysfunction: mechanisms and functional assessment. Nat Rev Cardiol. 2015 Jan;12(1):48-62.
Crea F, Camici PG, Bairey Merz CN: Coronary microvascular dysfunction: An update. Eur Heart J. 2014 May;35(17):1101-11.
Camici PG, Rimoldi OE, Gaemperli O and Libby P: Non-invasive Anatomic and Functional Imaging of Vascular Inflammation and Unstable Plaque. Eur Heart J. 2012; 33: 1309–1317.
Camici PG, Prasad S, Rimoldi O: Stunning, hibernation and assessment of viability. Circulation 2008:117: 103-114.
Camici PG, Crea F: Coronary microvascular dysfunction. New Engl J Med 2007; 356:830-40.
Cecchi F, Gistri R, Olivotto I, Lorenzoni R, Chiriatti G, Camici PG: Impaired coronary microvascular function as an independent prognostic predictor in patients with hypertrophic cardiomyopathy. New Engl J Med 2003;349:1027-35.
Wijns W, Vatner SF, Camici PG: Hibernating myocardium. N Engl J Med 1998; 339:173-181.
Rosen SD, Paulesu E, Nihoyannopoulos P, Tousoulis D, Frackowiack RSJ, Frith SD, Jones T, Camici P.G.: Silent ischaemia as a central problem: regional brain activation compared in silent and painful myocardial ischemia. Ann Int Med 1996; 124; 939-949.
Uren NG, Melin JA, De Bruyne B, Wijns W, Baudhuin T, Camici PG: Relation between myocardial blood flow and the severity of coronary artery stenosis. New Engl J Med 1994; 330: 1782-1788.