Translational Genomics and Bioinformatics



Giovanni Tonon



The primary goal of the Center for Translational Genomics and Bioinformatics (CTGB) at the IRCCS Ospedale San Raffaele is to provide to the scientific and clinical community technologies, approaches and instruments to understand the role of the genome on diseases development, diagnosis and cure. The center promotes genomic research integrated with translational medicine, to shed light into disease onset mechanisms, propose new ad-hoc therapies and improve patients’ assistance. 


The CTGB is organised in 4 research areas, i.e. genomics, bioinformatics, innovation and human health genomics. It is located in the DIBIT2 building and counts more than 30 scientists with a large variety of expertise and backgrounds. It is characterised by a truly interdisciplinary environment, aimed to provide scientific excellence and innovation on next-generation sequencing techniques and bioinformatics analysis.  

The Center already collaborates with many clinicians, research groups and institutes in Italy and abroad, and has been involved in over a thousand of projects

Research activity

The CTGB supports and initiates novel, interdisciplinary research, projecting IRCCS Ospedale San Raffaele towards tackling disease through-omics driven translational approaches. The Center acts as a catalyst for innovative research projects by complementing existing research lines across the Institute with high throughput technologies, quantitative methods, and powerful data mining techniques.  

The CTGB works with clinicians from all the clinical departments and is involved in several projects aimed to study cancer genomics and genetic diseases.  

The main research activities are:

  • Human Health Genomics  aimed to develop new diagnostic, predictive and therapeutic approaches; 
  • Transcriptome studies, to understand the mechanism of gene regulation and pathways involved in various physiological and pathological phenotypes; 
  • Epigenomics studies to find out the role of the environment in the onset of several diseases; 
  • Multi-omics  studies integrating different types of analysis; 
  • Development of new bioinformatic tools. 


July 12, 2019
Seminar held by Dr. Stefano Berto 
“The genomic underpinnings of oscillatory biomarkers supports successful memory encoding in humans”
15:00 - Aula Nina

Connect with us

The center serves as a nexus for integrating genomic research with translational medicine. CTGB advances scientific progress by helping researchers and clinicians generate, manage, and understand genomics data, through sequencing and bioinformatics services, interpretive collaborations and training.