Experimental oncology

Gastrointestinal surgery

team-item

Head of Unit

Riccardo Rosati

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Hospital division headed by Prof. Rosati treats approximately 2.000 surgical cases per year. The research activity is mainly clinical, focused on diseases of the gastrointestinal tract. Many unicentric and multicentric trials on esophagogastric and colorectal disease are ongoing in the division. 

Research activity

Concerning esophageal and gastric cancer, the principal trials are:
  • stomach trial: randomized multicentric study on minimally invasive vs open gastrectomy in patients with gastric cancer after neoadjuvant therapy;
  • indocyanine green fluorescence angiography: unicentric study addressed to the intraoperative evaluation of visceral substitute vascularization with this cyanine dye. This project is ongoing also in colorectal surgery, with the aim to improve clinical results reducing the incidence of anastomotic leaks.
Concerning basic research, two trials are ongoing:
  • GEA (Gastro-Esophageal cancer Annotated platform): observational multicentric study on precision medicine in gastroesophageal cancer patients, in order to correlate clinico-pathological features of the tumor with molecular profiling. Aim of this study is the creation of patient derived xenografts for possible genotype/response to therapy correlation
  • study on T lymphocyte response against mutation-derived tumor antigens in patients affected by locally advanced esophageal cancer stratified based on the response to neoadjuvant chemoradiotherapy. Aim of this study is to verify that complete pathological response to neoadjuvant treatment correlates to an elevated immunological response against mutation-derived tumor antigens.