Hospital division headed by Prof. Rosati treats approximately 2.000 surgical cases per year. The research activity is mainly clinical, focused on diseases of the gastrointestinal tract. Many unicentric and multicentric trials on esophagogastric and colorectal disease are ongoing in the division.
- stomach trial: randomized multicentric study on minimally invasive vs open gastrectomy in patients with gastric cancer after neoadjuvant therapy;
- indocyanine green fluorescence angiography: unicentric study addressed to the intraoperative evaluation of visceral substitute vascularization with this cyanine dye. This project is ongoing also in colorectal surgery, with the aim to improve clinical results reducing the incidence of anastomotic leaks.
- GEA (Gastro-Esophageal cancer Annotated platform): observational multicentric study on precision medicine in gastroesophageal cancer patients, in order to correlate clinico-pathological features of the tumor with molecular profiling. Aim of this study is the creation of patient derived xenografts for possible genotype/response to therapy correlation
- study on T lymphocyte response against mutation-derived tumor antigens in patients affected by locally advanced esophageal cancer stratified based on the response to neoadjuvant chemoradiotherapy. Aim of this study is to verify that complete pathological response to neoadjuvant treatment correlates to an elevated immunological response against mutation-derived tumor antigens.
de Pascale S, Repici A, Puccetti F, Carlani E, Rosati R, Fumagalli U. Peroral endoscopic myotomy versus surgical myotomy for primary achalasia: single-center, retrospective analysis of 74 patients. Dis Esophagus. 2017 Aug 1;30(8):1-7.
Vignali A, Elmore U, Lemma M, Guarnieri G, Radaelli G, Rosati R. Intracorporeal versus extracorporeal anastomoses following laparoscopic right colectomy in obese patients: a case-matched study. Dig Surg. 2017 Aug 3. doi: 10.1159/000479241.
Bergamini AN, Parise P, Cossu A, Adamenko O, Elmore U, Rosati R. Treatment of Zenker’s diverticulum with endoscopic stapled esophago-diverticulostomy (ESD): analysis of long-term outcome. Surg Laparosc Endosc Percutan Tech. 2017 Dec;27(6):445-448.
Gazzetta PG, Bissolati M, Saibene A, Ghidini CGA, Guarneri G, Giannone F, Adamenko O, Secchi A, Rosati R, Socci C. Bariatric surgery to target obesity in the renal transplant population: preliminary experience in a single center. Transplant Proc. 2017 May;49(4):646-649.
Vignali A, Elmore U, Cossu A, Lemma M, Calì B, de Nardi P, Rosati R. Enhanced recovery after surgery (ERAS) pathway vs traditional care in laparoscopic rectal resection: a single center experience. Tech Coloproctol. 2016 Aug;20(8):559-66.
De Manzoni G, Marrelli D, Baiocchi GL, Morgagni P, Saragoni L, Degiuli M, Donini A, Fumagalli U, Mazzei MA, Pacelli F, Tomezzoli A, Berselli M, Catalano F, Di Leo A, Framarini M, Giacopuzzi S, Graziosi L, Marchet A, Marini M, Milandri C, Mura G, Orsenigo E, Quagliuolo V, Rausei S, Ricci R, Rosa F, Roviello G, Sansonetti A, Sgroi G, Tiberio GA, Verlato G, Vindigni C, Rosati R, Roviello F. The Italian Research Group for Gastric Cancer (GIRCG) guidelines for gastric cancer staging and treatment: 2015. Gastric Cancer. 2017 Jan;20(1):20-30.
Parise P, Elmore U, Fumagalli U, De Manzoni G, Giacopuzzi S, Rosati R. Esophageal surgery in Italy: criteria to identify the hospital units and the tertiary referral centers entitled to perform it. Updates Surg 2016.
Fumagalli U, Rosati R, de Pascale S, Porta M, Carlani E, Pestalozza A, Repici A. Repeated surgical or endoscopic myotomy for recurrent dysphagia in patients after previous myotomy for achalasia. J Gastrointest Surg. 2016; 20:494-499.
Elmore U, Fumagalli Romario U, Vignali A, Sosa MF, Angiolini MR, Rosati R. Laparoscopic anterior resection with transanal total mesorectal excision for rectal cancer: preliminary experience and impact on postoperative bowel function. J Laparoendosc Adv Surg Tech A. 2015 Apr 28.
Rosati R, Fumagalli U, Elmore U, De Pascale S, Massaron S, Peracchia A. Long-term results of minimally invasive surgery for symptomatic epiphrenic diverticulum. Am J Surg 2011; 201 (1): 132-135.