Cellular and molecular allergology
Allergy is the phenotypic expression of a dysfunctional immune response, implying reactivity to antigens, called allergens, which per se are harmless to the host.
Our group is engaged in the characterization of immuno-dominance of individual components from complex allergenic sources and in the study of the spreading of the allergic response from single allergens to multiple allergens, in parallel with the clinical evolution of the so called “allergy march”.
Conti A, Burastero GJ, Suli C, Banerjee S, Vrtala S, Alessio M, Burastero SE. Identification by serological proteome analysis of paramyosin as prominent allergen in dust mite allergy. J Proteomics. 2017 Aug 23;166:19-26.
Burastero SE. T-cell receptor-mediated cross-reactivity to different allergens is driven by recognition of homologous, phylogenetically conserved epitopes. J Allergy Clin Immunol. 2016 Oct;138(4):1237.
Conti A, Alessio M, Pesca M, Soldarini A, Breda D, Pigatto PD, Burastero SE. Phleum pratense manganese superoxide dismutase identified by proteomic: a new candidate grass allergen. Ann Allergy Asthma Immunol. 2014 Mar;112(3):261.
Ferrari E, Breda D, Longhi R, Vangelista L, Nakaie CR, Elviri L, Casali E, Pertinhez TA, Spisni A, Burastero SE. In search of a vaccine for mouse allergy: significant reduction of Mus m 1 allergenicity by structure-guided single-point mutations. Int Arch Allergy Immunol. 2012;157(3):226-37.
Burastero SE, Frigerio B, Lopalco L, Sironi F, Breda D, Longhi R, Scarlatti G, Canevari S, Figini M, Lusso P. Broad-spectrum inhibition of HIV-1 by monoclonal antibody directed against a gp120-induced epitope of CD4. PLoS One. 2011;6(7):e22081.
Burastero SE, Masciulli A, Villa AM. Early onset of allergic rhinitis and asthma in recent extra-European immigrants to Milan, Italy: the perspective of a non-governmental organisation. Allergol Immunopathol (Madr). 2011;39(4):232-9.
Paolucci C, Ponti J, Fabbri MV, Breda D, Sabbioni E, Burastero SE. Platinum group elements enhance the allergic immune response by acting on dendritic cells. Int Arch Allergy Immunol. 2007;143:225-236.
Burastero SE, Paolucci C, Breda D, Ponti J, Munaro B, Sabbioni E. Chromium (VI)-induced immunotoxicity and intracellular accumulation in human primary dendritic cells. Int J Immunopathol Pharmacol. 2006;19:581-591.
Burastero SE. Three-year follow-up of clinical and inflammation parameters in children mono-sensitized to mites undergoing sublingual immunotherapy. Pediatr Allergy Immunol. 2006;17:318.
Crimi E, Gaffi D, Frittoli E, Borgonovo B, Burastero SE. Depletion of circulating allergen-specific TH2 T lymphocytes after allergen exposure in asthma. J Allergy Clin Immunol. 1997;99:788-797.
Burastero SE, Crimi E, Balbo A, Vavassori M, Borgonovo B, Gaffi D, Frittoli E, Casorati G, Rossi GA. Oligoclonality of lung T lymphocytes following exposure to allergen in asthma. J Immunol. 1995;155:5836-5846.
Burastero SE, Fenoglio D, Crimi E, Brusasco V, Rossi GA. Frequency of allergen-specific T lymphocytes in blood and bronchial response to allergen in asthma. J Allergy Clin Immunol. 1993;91:1075-1081.
Burastero SE, Casali P, Wilder RL, Notkins AL. Monoreactive high affinity and polyreactive low affinity rheumatoid factors are produced by CD5+ B cells from patients with rheumatoid arthritis. J Exp Med. 1988;168(6):1979-92.
Casali P, Burastero SE, Nakamura M, Inghirami G, Notkins AL. Human lymphocytes making rheumatoid factor and antibody to ssDNA belong to Leu-1+ B-cell subset. Science 1987;236(4797):77-81.