Location: DIBIT A3
Head, Leukocyte biology Unit
Full professor, Università Vita-Salute San Raffaele
Ruggero Pardi's most relevant scientific contribution is in the field of adhesion- dependent higher order responses. In the late ’80 he discovered that adhesion receptors are not mere "sticky" proteins but rather transduce signals contributing to complex biological responses in multiple cell types, ranging from proliferation to survival. RP went on to dissect the mechanisms linking integrin signaling to gene expression regulation, by identifying a novel signaling pathway involving the COP9 signalosome. The implications of this discovery extended to the comprehension of the mechanisms underlying loss of anchorage dependence in tumor cells, thus providing clues to early pathogenic events in tumorigenesis. RP has a long track of dedication in teaching and mentoring.
He has been teaching a basic pathology course to medical students since 2001, and has supervised over 20 graduate students during acquisition of scholarship and independence, both at the national and international level. Notably, he has coordinated several international consortia devoted to training and mentoring of graduate students at the European level and has pioneered the development of join curricula leading to the awarding of joint PhD titles by Universities from different EU member or associated States.