Immunology, Transplantation and Infectious Diseases
Vascular Pathobiology
We explore the intricate interplay of vascular biology, immunology, and chronic inflammation. At the core of our mission lies a fusion of cutting-edge microscopy and spatially-resolved multi-omics with a traditional pathologist’s approach to biological questions, enabling us to expand the boundaries of basic and clinical understanding. We focus on deciphering how blood vessels shape organ compartmentalization and drive the progression of metabolic and viral diseases, with a particular emphasis on chronic hepatitis.
Central to our research is the exploration of liver lobules. These intricate structures, defined by a unique vascular architecture, serve as the focal point for our investigations into the vascular control of chronic liver diseases. Our studies aim to decipher the complex interplay of blood vessels and immune cells within liver lobules, elucidating their critical roles in diseases like NASH and viral hepatitis. By analyzing zonation patterns and investigating the interactions between vascular endothelial cells and immune cells, we gain insights into disease mechanisms and potential therapeutic targets.
Research activity
Our investigation spans multiple dimensions, each revealing unique insights into the intricate workings of biological systems:
Mapping Gene Function in 3D uncovers the spatial organization of gene expression within tissues. Leveraging state-of-the-art spatial transcriptomics technologies, we map gene expression patterns in three-dimensional space, offering unprecedented insights into tissue architecture. By integrating this spatially resolved transcriptomic data with anatomical information, we deepen our understanding of how gene expression programs shape organ function.
In tandem, we investigate the dynamic behavior of blood vessels in health and disease. Our lab delves into the forefront of vascular biology research. Utilizing advanced imaging techniques and sophisticated computational analyses, we uncover new insights into the vascular control of organ function, shedding light on the intricate mechanisms governing blood vessel behavior.
Complementing this endeavor, Unraveling Immune Cell Signaling illuminates the complex interplay between the immune system and tissue function. Our research dissects the intricate signaling pathways governing immune cell behavior and function within specific anatomical contexts. Through this exploration, we uncover novel mechanisms of immune regulation and identify targets for therapeutic intervention.
