Location: DIBIT1 A3, Floor 3, Room 58
Senior researcher, Cellular neurophysiology Unit
Daniele Zacchetti and his colleagues investigate the steps in the neurodegenerative process by working with primary neuronal/glial cultures and cell lines. With cellular and molecular approaches, the aim is to dissect the pathogenetic events of neurodegenerative diseases and to understand the role of astrocyte and microglia activation in neuronal survival.
In particular, Daniele Zacchetti is trying to characterize the ways in which physiological and pathological stimuli can activate glial cells and the corresponding changes in their phenotype, including the secretion of proteins and small molecules affecting neuroinflammatory processes, neuronal activity and survival. Moreover, he investigates the expression of beta-secretase enzyme (BACE1) as a possible in Alzheimer’s disease
1989 Degree cum laude in Pharmaceutical Chemistry and Technology, University of Milano, Italy
1998-2001 Postdoc fellow, Cellular Neurophysiology Unit, IRCCS Ospedale San Raffaele, Milano, Italy
995-1997 Postdoc fellow, European Molecular Biology Laboratory, Heidelberg, Germany
1992-1994 Junior Scientist, Dibit, IRCCS Ospedale San Raffaele, Milano, Italy