Autoimmune disease results from the interplay between environmental and genetic factors. Recent studies indicated that autoimmune diseases like Type 1 Diabetes (T1D) are induced by genetic or environment-induced alterations of immune regulatory pathways whose function is to avoid or limit the activation/expansion of self-reactive T lymphocytes. The aim is to determine whether a defect of immuneregulation underlies the pathogenesis of autoimmune diabetes in mice and humans and to restore those regulatory pathways for prevention/treatment of T1D.
Di Pietro C, De Giorgi L, Cosorich I, Sorini C, Fedeli M and Falcone M. miRNA-133b regulation of Th-POK expression and dendritic cell signals affect NKT17 cell differentiation in the thymus. J Immunol. 2016 Oct 15;197(8):3271-3280.
Dolpady J, Sorini C, Di Pietro C, Cosorich I, R Ferrarese, D Saita, M Clementi, F Canducci, Falcone M. Oral probiotic VSL#3 prevents T1D by modulating microbiota and promoting indoleamine 2,3-dioxygenase (IDO)-enriched tolerogenic intestinal environment. J Diab Res. 2016;2016:7569431.
Betto E, Usuelli V, Mandelli A, Sorini C, Badami E, Capolla S, Danelli L, Frossi B, Guarnotta C, Ingrao S, Tripodo C, Pucillo C, Gri G, Falcone M. Mast cells promote autoimmune diabetes by favoring effector Th17 cell differentiation. Clinical Immunology 2015. S1521-6616(15)30082-6.
Di Pietro C, Falcone M. The role of invariant NKT cells in organ-specific autoimmunity. Front Biosci. 2014 Jun 1;19:1240-50.
Sorini C, Falcone M. Shaping the (auto)immune response in the gut: the role of intestinal immune regulation in the prevention of type 1 diabetes. Am J Clin Exp Immunol. 2013 Jun 15;2(2):156-71.
Badami E, Sorini C, Coccia M, Molteni L, Bolla AM, Scavini M, Mariani A, Bosi E, Falcone M. Defective differentiation of regulatory FoxP3+ T cells by small intestinal dendritic cells in Type 1 Diabetic patients. Diabetes 2011 Aug;60(8):2120-4.
McGuire HM, Vogelzang A, Ma CS, Hughes WE, Silveira PA, Tangye SG, Christ D, Fulcher D, Falcone M, King C. Subset of interleukin-21(+) chemokine receptor CCR9(+) T helper cells target accessory organs of the digestive system in autoimmunity. Immunity 2011. 34(4):602-15.
Caielli S, Sorini C, Falcone M. The dangerous liaison between iNKT cells and dendritic cells: does it prevent or promote autoimmune diseases? Autoimmunity 2011 Feb;44(1):11-22.
Baev DV, Caielli S., Ronchi F, Coccia M, Facciotti F, Nichols KE, Falcone M. Impaired SLAM-SLAM homotypic interaction between invariant NKT cells and dendritic cells affects differentiation of IL-4/IL-10-secreting NKT2 cells in NOD mice. J Immunol. 2008. 181(2): 869.
Ronchi F, Falcone M. Immune regulation by invariant NKT cells in autoimmunity. Front Biosci. 2008 Feb;13(13):4827-37.