Postdoctoral position at Kajaste-Rudnitski lab
A post-doctoral fellow position is immediately available in the Retrovirus-Host Interactions and Innate Immunity to Gene Transfer Lab, led by Anna Kajaste-Rudnitski at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, Italy.
Aberrant sensing of nucleic acids originating from the expression of endogenous retroviral elements or accumulating DNA damage and consequent increase in type I IFN levels have been suggested to be a primary driver of pathogenesis of the Aicardi-Goutières Syndrome (AGS), a genetic Leukodystrophy that mainly affects the brain, immune system and skin. Nevertheless, the precise molecular mechanisms triggering the disease remain elusive. On these premises, we are recruiting a post-doctoral fellow with strong experience in iPSC-based differentiation of Neural Stem Cells and Progenitor and/or innate immunity to viral infections to work on a project aimed at evaluating the consequences of the AGS gene defects in the human Central Nervous Systems (CNS) taking advantage of iPSC based in vitro differentiations. The goal is to elucidate the role of different cell types of the CNS, including microglia, in AGS and to investigate what are the endogenous signals that aberrantly activate the disease-causing antiviral responses in these cells. We combine molecular virology approaches with state-of-the-art NGS technology and proteomics in the highly relevant context of human iPSC-based in vitro disease models.
As part of the SR-TIGET, a world-leading Institute in the fields of gene and cell therapy for the treatment of human genetic diseases, we benefit from a highly competitive, international and scientifically stimulating environment and offer excellent working conditions, training opportunities, state-of-the-art facilities and infrastructures (NextGeneration Sequencing, Cell Sorting and Imaging, Animal Facilities), and access to clinically relevant human samples.
The successful candidate will be offered a 1-year starting contract with possible extension thereafter and a competitive salary, negotiated depending on experience. To have more information and to apply, click here.