Antonella Castagna has a broad background in the management of HIV-1 infected patients and her research included the control of opportunistic infections and long-term non HIV complications (cardiovascular risk, cirrhosis, cancer, diabetes) and antiretroviral drugs, the evaluation of new therapeutic strategies aimed at reducing ART toxicity and management of multidrug-resistance as well as the evaluation of clinical implications associated with the occurrence of residual viremia. Her current research interests are in the field of HIV reservoirs and on the interventions aimed at reducing these reservoirs. In addition, she successfully administered several projects funded by national and international agencies, collaborated with other researchers, and produced several peer-reviewed publications from each project. A distinct characteristic of her work is the attention to the “clinical relevance” of the projects to ensure that, where possible, any outputs can be translated into improvements in clinical care.