Clinical research
Gastro center
Mission
Gastro Center collects professionals from various specialities to collaborate in a strongly connected setting to improve research and care of diseases affecting the upper gastrointestinal tract. The multidisciplinary approach with representatives of different disciplines is the milestone of optimal care and support to patients. Our approach is focused on clinic, and includes a special interest in research, clinical and translational, with cooperation between basic science and the real word of everyday medicine, aiming to treat the single patient as well as sustain the scientific environment to achieve scientific knowledge. A particular personalized approach is guaranteed to all the patients that are continuously monitored in all the phases of their care process (pre-hospital, in-hospital, follow-up after discharge) thanks to the active presence of the “navigator nurse”. All the data are securely managed by a professional data manager.
Our goals include effective prevention by screening and managing of risk factors, prompt diagnosis and rapid referral, prompt access to best care. Moreover, our rich bio-bank, is used for molecular and genetic research.
Diagnosis and treatment are specifically designed upon the patient complains and needs, to improve outcomes, by sharing information weekly on our multidisciplinary team meeting and promptly plan and manage future steps.
Organization
Malignancy of the upper GI tract is the major field of interest. The multidisciplinary team includes different figures involved in the diagnostic, clinic and research pathway:
- surgeons,
- gastroenterologists,
- oncologists,
- radiologists,
- radiation oncologists,
- nuclear medicine physicians,
- pathologists,
- anesthesiologists and pain management team specialist,
- biologists,
- physiotherapists,
- nurses,
Functional and benign disease of the esophagus are also matter of separate meetings with dedicated gastroenterologist and expert physiopathologists.
Research
The team has a strong focus on multidisciplinary education and research in all the aspects of upper GI and collaborates with Vita-Salute University School of Medicine. Our center promotes mentoring of younger physicians, medical students and international fellows who are involved in clinical practice and research activities. Web courses with live procedures and webinars, are regularly offered.
Our research fields include every clinical and pre-clinical phases, ranging from genetics and immunology of upper-GI cancers to most advanced surgical techniques, and to clinical management of patients with particular attention to pre, intra, and post-operative settings.
De Cobelli F, Palumbo D, Albarello L, Rosati R, Giganti F. Esophagus and Stomach: Is There a Role for MR Imaging? Magn Reson Imaging Clin N Am. 2020 Feb;28(1):1-15.doi: 10.1016/j.mric.2019.08.001.
Gianotti L, Fumagalli Romario U, De Pascale S, Weindelmayer J, Mengardo V, Sandini M, Cossu A, Parise P, Rosati R, Bencini L, Coratti A, Colombo G, Galli F, Rausei S, Casella F, Sansonetti A, Maggioni D, Costanzi A, Bernasconi DP, De Manzoni G. Association Between Compliance to an Enhanced Recovery Protocol and Outcome After Elective Surgery for Gastric Cancer. Results from a Western Population-Based Prospective Multicenter Study. World J Surg. 2019
Parise P, Ferrari C, Cossu A, Puccetti F, Elmore U, De Pascale S, Garutti L, Fumagalli UR, Di Serio MS, Rosati R.Enhanced Recovery After Surgery (ERAS)Pathway in Esophagectomy: Is a Reasonable Prediction of Hospital Stay Possible? Ann Surg. 2019 Jul;270(1):77-83. doi: 10.1097/SLA.0000000000002775.
Hagens ERC, van Berge Henegouwen MI, van Sandick JW, Cuesta MA, van der Peet DL, Heisterkamp J, Nieuwenhuijzen GAP, Rosman C, Scheepers JJG, Sosef MN, van Hillegersberg R, Lagarde SM, Nilsson M, Räsänen J, Nafteux P, Pattyn P, Hölscher AH, Schröder W, Schneider PM, Mariette C, Castoro C, Bonavina L, Rosati R, de Manzoni G, Mattioli S, Garcia JR, Pera M, Griffin M, Wilkerson P, Chaudry MA, Sgromo B, Tucker O, Cheong E, Moorthy K, Walsh TN, Reynolds J, Tachimori Y, Inoue H, Matsubara H, Kosugi SI, Chen H, Law SYK, Pramesh CS, Puntambekar SP, Murthy S, Linden P, Hofstetter WL, Kuppusamy MK, Shen KR, Darling GE, Sabino FD, Grimminge PP, Meijer SL, Bergman JJGHM, Hulshof MCCM, van Laarhoven HWM, Mearadji B, Bennink RJ, Annema JT, Dijkgraaf MGW, Gisbertz SS. Distribution of lymph node metastases in esophageal carcinoma [TIGER study]: study protocol of a multinational observational study. BMC Cancer. 2019 Jul 4;19(1):662. doi:10.1186/s12885-019-5761-7
Parise P, Cinelli L, Ferrari C, Cossu A, Puccetti F, Garutti L, Elmore U, Rosati R. Early Red Flags Associated with Delayed Discharge in Patients Undergoing Gastrectomy: Analysis of Perioperative Variables and ERAS Protocol Items. World J Surg. 2020 Jan;44(1):223-231. doi: 10.1007/s00268-019-05223-4.
de Pascale S, Repici A, Puccetti F, Carlani E, Rosati R, Fumagalli U. Peroral endoscopic myotomy versus surgical myotomy for primary achalasia: single-center, retrospective analysis of 74 patients. Dis Esophagus. 2017 Aug 1;30(8):1-7.doi: 10.1093/dote/dox028.
Mazza M, Bergamini AN, Parise P, Cossu A, Adamenko O, Elmore U, Rosati R. Treatment of Zenker’s Diverticulum With Endoscopic Stapled Esophago-divertisculostomy (ESD): Analysis of Long-term Outcome.urg Laparosc Endosc Percutan Tech. 2017 Dec;27(6):445-448. doi: 10.1097/SLE.0000000000000473.
Fumagalli Romario U, Weindelmayer J, Coratti A, Cossu A, Gianotti L, Rausei S,Sansonetti A, De Pascale S; Italian Group for Enhanced Recovery in Gastric Surgery (ERGS). Enhanced recovery after surgery in gastric cancer: which are the main achievements from the Italian experience? Updates Surg. 2018 Jun;70(2):257-264. doi: 10.1007/s13304-018-0522-8.
Parise P, Elmore U, Fumagalli U, De Manzoni G, Giacopuzzi S, Rosati R. Esophageal surgery in Italy. Criteria to identify the hospital units and the tertiary referral centers entitled to perform it. Updates Surg. 2016 Jun;68(2):129-33
Milone M, Elmore U, Musella M, Parise P, Zotti MC, Bracale U, Di Lauro K, Manigrasso M, Milone F, Rosati R.Safety and efficacy of laparoscopic wedge gastrectomy for large gastrointestinal stromal tumors.Eur J Surg Oncol. 2017 Apr;43(4):796-800. doi: 10.1016/j.ejso.2017.01.005.
Rosati R, Parise P, Giannone Codiglione F. Technical pro & cons of the laparoscopic lymphadenectomy.Transl Gastroenterol Hepatol. 2016 Dec 27;1:93. doi: 10.21037/tgh.2016.12.04.