Genetics and cell biology
The mission of Genetics and cell biology Division is the comprehension of biological and pathological phenomena, as this is fundamental to cure disease and create novel biotechnologies. The division hosts curiosity-driven projects of innovative investigators, and structured programs on areas of particular interest and strength. The division tries to balance curiosity driven research and team-networking organization, fostering quality science, and producing knowledge transferable to the Clinics or other thematic Divisions. Recruiting excellent scientists, providing suitable technological platforms, tightening the relationships between basic and clinical scientists and promoting areas of strength are key parts of the division's mission.
The Division of Genetics and Cell Biology (DGCB) hosts many basic research units, totalling over 100 persons. View all the research units here.
DGCB hosts both PhD and Postdoctoral training programs related to Università Vita-Salute San Raffaele, where positions are offered on a competitive basis for a minimum of 3 and 2 years, respectively.
Cutting edge areas in the divions are the physiopathology of cell stress and iron metabolism, chromatin dynamics, genetics and epigenetics. Internationally competitive groups are working in cell adhesion, migration and polarity. A program with fertile interdivisional links is bone and cartilage physiopathology (Bonetwork). Molecular mechanism underlying diseases (conformational diseases, cystic kidney disorders, neuromuscular diseases, inflammation, iron-related diseases, disorders of human reproduction, osteoporosis and bone diseases) are being investigated by many groups with robust animal and cellular models and patients’ biological samples.
These lines of investigation address important medical issues in which existing synergies between basic and clinical sciences are being fostered, increasing our funding potentials and translational outputs. DGCB provides the clinics with concepts and protocols to be tested, at the same time the reverse translation takes place: detailed analysis of cohorts of patients can help unravel physiological mechanisms.
Group leader, In vivo chromatin and transcription Unit
Head, Chromatin dynamics Unit
Head, Molecular basis of cystic kidney disorders Unit
Head, Regulation of iron metabolism Unit
Group leader, Cancer metabolism Unit
Head, Age related diseases Unit
Group leader, Biology of myelin Unit
Head, Gene expression and muscular dystrophy Unit
Head, Genomics of renal diseases and hypertension Unit
Group leader, Pediatric endocrinology Unit
Head, Biomolecular nuclear magnetic resonance Unit
Head, Molecular genetics of renal disorders Unit
Head, Osteoporosis and bone and mineral metabolism Unit
Maria Vittoria Schiaffino
Head, Organelle biogenesis and motility Unit
Head, Protein transport and secretion Unit
Eelco van Anken
Group leader, Intracellular signaling pathways
Group leader, Reproductive sciences Unit
Age related diseases
Biology of myelin
Marco Emilio Bianchi
Gene expression and muscular dystrophy
Genomics of renal diseases and hypertension
Intracellular signaling pathways
Eelco van Anken
In vivo chromatin and transcription
Molecular basis of cystic kidney disorders
Molecular genetics of renal disorders
Organelle biogenesis and motility
Maria Vittoria Schiaffino
Osteoporosis and Bone and Mineral Metabolism
Protein transport and secretion
Regulation of iron metabolism
The molecular switch behind muscle formation
Researchers discovered the first molecular switch activating muscle formation, whose malfunction is involved in diseases such as muscular dystrophy
Discovered two epigenetic regulators of metabolism
The study discovered two enzymes which are able to slow down the body's metabolism and could pave the way for new therapeuthic approaches to obesity
Two postdoctoral positions in cancer metabolism are immediately available in the Cancer metabolism Unit, headed by Simone Cardaci
One junior position is available at Age Related Diseases Unit, headed by Simone Cenci, since January 2020
A postdoctoral position is available in Roberto Sitia's lab to work on the mechanisms linking cellular stress responses to the dynamics of ER – mitochondria contacts.