Pancreas translational and clinical Center
The mission of the Pancreas translational and clinical Center is to create an integrated pathway for pancreatic diseases, transversal to all clinical specialties, through a multidisciplinary team of clinical experts and researchers in the field of Surgery, Gastroenterology, Pathology, Nuclear Medicine, Radiology, Radiotherapy, Oncology, all working side by side with basic science researchers.
Our view of pancreatic disorders considers the patients at the very center of a holistic clinical process and considers personalized medicine as a tool toward better clinical results.
To this aim, we investigate not only clinical strategies based on pathological, clinical and molecular features, but also the relevance of patient-reported outcomes and patient-reported experience measures, and take care of nutritional and psychological aspects of pancreatic disorders.
The Pancreas translational and clinical Center of IRCCS Ospedale San Raffaele includes clinicians from different units in a fluid organization:
The whole of two Units: Pancreatic Surgery and PancreatoBiliary Endoscopy and Endoscopic Ultrasound constitute the backbone of the Center, with the following Clinical Units being involved with dedicated delegates in the Center’s Executive Board:
- Nuclear Medicine
- Diabetes Research Institute
- Clinical Nutrition
- Anesthesia and Pain Management
This organization involves over 100 personnel in a translational medicine setting. All cases are discussed in dedicated multidisciplinary “disease unit” meetings to establish the best clinical path.
Data Managers, Research and Navigators Nurses complete the Team and are active part of the clinical and research activities.
Members of the Center are part of the faculty of Università Vita-Salute San Raffaele. Residency programs, PhD programs and Post-Doc positions are active in the Center as Research couples with Teaching.
Several experts from the Center are involved in the design and implementation of major national and international guidelines for the clinical care of Pancreatic Adenocarcinoma, Pancreatic Cystic Lesions, care of individuals at increased familial risk of Pancreatic Cancer, Autoimmune Pancreatitis, Acute and Chronic Pancreatitis and Neuroendocrine Tumours.
Clinical and basic researchers work together to investigate key and hot issues in pancreatic disorders with a particular interest on Pancreatic Adenocarcinoma, Pancreatic Cystic Lesions, Neuroendocrine Tumours, Acute and Chronic Pancreatitis.
Several competitive grants have been assigned to researchers working on Pancreatic Disorders in the Center. Specifically, preclinical and clinical studies on factors affecting efficacy of medical treatments, variables associated with progression of preneoplastic lesions, and success of experimental oncological or locally ablative treatments on pancreatic neoplasms including registered Randomized Controlled Trials is ongoing.
A total of 65 peer-reviewed articles have been published by the members of the Center in 2019 and 71 in the first seven months of 2020.
Partelli S, Bartsch DK, Capdevila J, Chen J, Knigge U, Niederle B, Nieveen van Dijkum EJ, Pape UF, Pascher A, Ramage J, Reed N, Ruszniewski P, Scoazec JY, Toumpanakis C, Kianmanesh R, Falconi M; all other Antibes Consensus Conference participants. ENETS Consensus Guidelines for Standard of Care in Neuroendocrine Tumours: Surgery for Small Intestinal and Pancreatic Neuroendocrine Tumours. Neuroendocrinology. 2017;105(3):255-265.
Scarpa A, Chang DK, Nones K, Corbo V, Patch AM, Bailey P, Lawlor RT, Johns AL, Miller DK, Mafficini A, Rusev B, Scardoni M, Antonello D, Barbi S, Sikora KO, Cingarlini S, Vicentini C, McKay S, Quinn MC, Bruxner TJ, Christ AN, Harliwong I, Idrisoglu S, McLean S, Nourse C, Nourbakhsh E, Wilson PJ, Anderson MJ, Fink JL, Newell F, Waddell N, Holmes O, Kazakoff SH, Leonard C, Wood S, Xu Q, Nagaraj SH, Amato E, Dalai I, Bersani S, Cataldo I, Dei Tos AP, Capelli P, Davì MV, Landoni L, Malpaga A, Miotto M, Whitehall VL, Leggett BA, Harris JL, Harris J, Jones MD, Humphris J, Chantrill LA, Chin V, Nagrial AM, Pajic M, Scarlett CJ, Pinho A, Rooman I, Toon C, Wu J, Pinese M, Cowley M, Barbour A, Mawson A, Humphrey ES, Colvin EK, Chou A, Lovell JA, Jamieson NB, Duthie F, Gingras MC, Fisher WE, Dagg RA, Lau LM, Lee M, Pickett HA, Reddel RR, Samra JS, Kench JG, Merrett ND, Epari K, Nguyen NQ, Zeps N, Falconi M, Simbolo M, Butturini G, Van Buren G, Partelli S, Fassan M; Australian Pancreatic Cancer Genome Initiative, Khanna KK, Gill AJ, Wheeler DA, Gibbs RA, Musgrove EA, Bassi C, Tortora G, Pederzoli P, Pearson JV, Waddell N, Biankin AV, Grimmond SM. Whole-genome landscape of pancreatic neuroendocrine tumours. Nature 2017 Mar 2;543(7643):65-71.
Crippa S, Pezzilli R, Bissolati M, Capurso G, Romano L, Brunori MP, Calculli L, Tamburrino D, Piccioli A, Ruffo G, Fave GD, Falconi M. Active surveillance beyond 5 years is required for presumed branch-duct intraductal papillary mucinous neoplasms undergoing non-operative management. Am J Gastroenterol. 2017 Jul;112(7):1153-1161.
Crippa S, Bassi C, Salvia R, Malleo G, Marchegiani G, Rebours V, Levy P, Partelli S, Suleiman SL, Banks PA, Ahmed N, Chari ST, Fernández-Del Castillo C, Falconi M. Low progression of intraductal papillary mucinous neoplasms with worrisome features and high-risk stigmata undergoing non-operative management: a mid-term follow-up analysis. Gut 2017 Mar;66(3):495-506.
Falconi M, Eriksson B, Kaltsas G, Bartsch DK, Capdevila J, Caplin M, Kos-Kudla B, Kwekkeboom D, Rindi G, Klöppel G, Reed N, Kianmanesh R, Jensen RT; Vienna Consensus Conference participants. ENETS Consensus Guidelines Update for the Management of Patients with Functional Pancreatic Neuroendocrine Tumors and Non-Functional Pancreatic Neuroendocrine Tumors. Neuroendocrinology 2016;103(2):153-71.
Jais B, Rebours V, Malleo G, Salvia R, Fontana M, Maggino L, Bassi C, Manfredi R, Moran R, Lennon AM, Zaheer A, Wolfgang C, Hruban R, Marchegiani G, Fernández Del Castillo C, Brugge W, Ha Y, Kim MH, Oh D, Hirai I, Kimura W, Jang JY, Kim SW, Jung W, Kang H, Song SY, Kang CM, Lee WJ, Crippa S, Falconi M, Gomatos I, Neoptolemos J, Milanetto AC, Sperti C, Ricci C, Casadei R, Bissolati M, Balzano G, Frigerio I, Girelli R, Delhaye M, Bernier B, Wang H, Jang KT, Song DH, Huggett MT, Oppong KW, Pererva L, Kopchak KV, Del Chiaro M, Segersvard R, Lee LS, Conwell D, Osvaldt A, Campos V, Aguero Garcete G, Napoleon B, Matsumoto I, Shinzeki M, Bolado F, Fernandez JM, Keane MG, Pereira SP, Acuna IA, Vaquero EC, Angiolini MR, Zerbi A, Tang J, Leong RW, Faccinetto A, Morana G, Petrone MC, Arcidiacono PG, Moon JH, Choi HJ, Gill RS, Pavey D, Ouaïssi M, Sastre B, Spandre M, De Angelis CG, Rios-Vives MA, Concepcion-Martin M, Ikeura T, Okazaki K, Frulloni L, Messina O, Lévy P. Serous cystic neoplasm of the pancreas: a multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas). Gut. 2016 Feb;65(2):305-12.
Partelli S, Inama M, Rinke A, Begum N, Valente R, Fendrich V, Tamburrino D, Keck T, Caplin ME, Bartsch D, Thirlwell C, Fusai G, Falconi M. Long-Term outcomes of surgical management of pancreatic neuroendocrine tumors with synchronous liver metastases. Neuroendocrinology 2015;102(1-2):68-76.
Falconi M, Crippa S, Chari S, Conlon K, Kim SW, Levy P, Tanaka M, Werner J, Wolfgang CL, Pezzilli R, Castillo CF. Quality assessment of the guidelines on cystic neoplasms of the pancreas. Pancreatology 2015 Sep-Oct;15(5):463-469.
Gaujoux S, Partelli S, Maire F, D'Onofrio M, Larroque B, Tamburrino D, Sauvanet A, Falconi M, Ruszniewski P. Observational study of natural history of small sporadic nonfunctioning pancreatic neuroendocrine tumors. J Clin Endocrinol Metab. 2013 Dec;98(12):4784-9.
Tanaka M, Fernández-del Castillo C, Adsay V, Chari S, Falconi M, Jang JY, Kimura W, Levy P, Pitman MB, Schmidt CM, Shimizu M, Wolfgang CL, Yamaguchi K, Yamao K; International Association of Pancreatology. International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology 2012 May-Jun;12(3):183- 97.