Institutes
Urological Research Institute
The Urological Research Institute holds unique opportunities to address and investigate a variety of aspects of urogenital disorders (epidemiological, genetic, molecular, cellular, physiological and pharmacological) of immediate relevance for individual patients as well as health-care systems. Our research program aims at producing an inspiring scientific environment where clinical research and basic research in urology and urological pharmacology interact on a daily basis.
Organization
The Urological Research Institute, located in San Michele 2 building of IRCCS Ospedale San Raffaele campus, performs its activity in close collaboration with the clinical urological unit of IRCCS Ospedale San Raffaele.
URI translational research projects are possible also thanks to an impressive volume of biological samples stored in a dedicated biobank and of data collected by more than 30.000 patients during the years.
Research
The Urological Research Institute studies a variety of urogenital pathologies, with a special focus on prostate, bladder and renal tumors, as well as sexual and reproductive dysfunctions.
Basic research projects
- Genetics factors and inheritance of prostate cancer;
- Nanotechnologies for effective delivering of chemotherapy in bladder cancer;
- Extracellular microenvironment in prostate/bladder tumors and in male infertility.
Clinical research projects
- The role of hormones as a risk and severity factor in prostate cancer;
- The efficacy of radiotherapy in urogenital tumors;
- Factors involved in the emergence of urinary incontinence and erectile dysfunction after surgery;
- Spreading patterns of metastasis from urogenital tumors;
- Conservative renal surgery and therapeutic efficacy of lymph nodes removal in urogenital tumors surgery treatment;
Umberto Capitanio
Group leader, Kidney cancer Unit
Ilaria Cavarretta
Staff researcher, Prostate cancer biomarkers
Alberto Briganti
Group leader, Prostate cancer Unit
Andrea Gallina
Staff physician scientist, Bladder cancer
Giorgio Gandaglia
Senior researcher, Prostate cancer: outcome research
Giovanni Lavorgna
Staff researcher, Long-noncoding RNA and computational research
Isaline Rowe
Staff researcher, VHL syndrome and kidney cancer
Andrea Salonia
Group leader, Non-oncology and rare uro-andrological diseases Unit
Francesco Trevisani
Staff physician scientist, Experimental onco-nephrology
Riccardo Vago
Staff researcher, Extracellular vesicles and toxins
Massimo Alfano
Group leader, Extracellular microenvironment Unit
Data manager position is available at Urologial Research Institute (URI), headed by Andrea Salonia
Lavorgna G, Montorsi F, Salonia A. Re: Ken J. Kron, Alexander Murison, Stanley Zhou, et al. TMPRSS2-ERG fusion co-opts master transcription factors and activates NOTCH signaling in primary prostate cancer. Nat Genet 2017;49:1336-45. Eur Urol. 2018 Apr;73(4):e106-e107.
Di Trapani E, Nini A, Locatelli I, Buono R, Russo A, Dell'Oglio P, Castiglione F, La Croce G, Benigni F, Montorsi F, Salonia A, Cavarretta I*, Briganti A*. Development of the first model of radical prostatectomy in the mouse: a feasibility study. Eur Urol. 2018 Mar; 73(3):482–484.
Cavarretta I, Ferrarese R, Cazzaniga W, Saita D, Lucianò R, Ceresola ER, Locatelli I, Visconti L, Lavorgna G, Briganti A, Nebuloni M, Doglioni C, Clementi M, Montorsi F, Canducci F, Salonia A. The microbiome of the prostate tumor microenvironment. 2017 Eur Urol. 72:625-631.
Trevisani F, Larcher A, Cinque A, Capitanio U, Ripa F, Vago R, Bettiga A, Benigni F, Carenzi C, Muttin F, Bertini R, Briganti A, Salonia A, Rampoldi L, Montorsi F. The association of uromodulin genotype with renal cancer aggressiveness. Eur. Urol. Focus. 2017 May; S2405-4569(17):30115-3.
Giacomini E, Vago R, Sanchez AM, Podini P, Zarovni N, Murdica V, Rizzo R, Bortolotti D, Candiani M, Viganò P. Secretome of in vitro cultured human embryos contains extracellular vesicles that are uptaken by the maternal side. Sci. Rep. 2017 Jul 12;7(1):5210.
Alfano M, Ventimiglia E, Locatelli I, Capogrosso P, Cazzaniga W, Pederzoli F, Frego N, Matloob R, Saccà A, Pagliardini L, Viganò P, Zerbi P, Nebuloni M, Pontillo M, Montorsi F, Salonia A. Anti-Mullerian hormone-to-testosterone ratio is predictive of positive sperm retrieval in men with idiopathic non-obstructive azoospermia. Sci Rep. 2017 Dec 15;7(1):17638.
Alfano M, Nebuloni M, Zerbi P, Salonia A. Male infertility and ageing: two faces of the same coin? Biochimica Clinica 2017, 41 (4).
Nini A, Capitanio U, Larcher A, Dell'Oglio P, Dehò F, Suardi N, Muttin F, Carenzi C, Freschi M, Lucianò R, La Croce G, Briganti A, Colombo R, Salonia A, Castiglioni A, Rigatti P, Montorsi F, Bertini R. Perioperative and oncologic outcomes of nephrectomy and caval thrombectomy using extracorporeal circulation and deep hypothermic circulatory arrest for renal cell carcinoma invading the supradiaphragmatic inferior vena cava and/or right atrium. Eur Urol. 2017 Sep 13. pii: S0302-2838(17)30712-1.
Larcher A, Muttin F, Fossati N, Dell'Oglio P, Di Trapani E, Stabile A, Ripa F, Trevisani F, Carenzi C, Picchio M, Briganti A, Salonia A, Mottrie A, Bertini R, Montorsi F, Capitanio U. When to perform preoperative bone scintigraphy for kidney cancer staging: indications for preoperative bone scintigraphy. Urology 2017 Dec;110:114-120.
Dell'Oglio P, Larcher A, Muttin F, Di Trapani E, Trevisani F, Ripa F, Carenzi C, Briganti A, Salonia A, Montorsi F, Bertini R, Capitanio U. Lymph node dissection should not be dismissed in case of localized renal cell carcinoma in the presence of larger diseases. Urol Oncol. 2017 Nov;35(11):662.e9-662.e15.