Experimental hematology

Chiara Bonini

Chiara Bonini

Email: bonini.chiara@hsr.it
Location: Dibit 1, Floor 3, Room A1
Group Leader, Experimental hematology
Full Professor, Università Vita-Salute San Raffaele

Her main research focus is the development, preclinical and clinical validation of cell and gene therapy approaches to treat cancer. 

She pioneered the clinical use of genetically engineered lymphocytes in the context of stem cell transplantation, leading to the first cell-based gene therapy product approved by EMA for oncologic diseases. 

Her group has extensive experience on cancer immunotherapy, genetic manipulation of T cells, including TCR/CAR gene transfer. In particular, she developed the TCR gene editing approach to completely and permanently redirect T cell specificity. 

An additional relevant activity of Bonini’s Team is represented by the Immunomonitoring sub-Unit. This section of the lab is dedicated to the analyses of immunological correlates with clinical outcome in the context of hematopoietic stem cell transplantation. This activity is becoming critical in the growing field of cellular therapy, and the lab has obtained the ISO 9001:2015 certification and the qualification for monitoring phase I clinical trials in conformity to AIFA requirements (determina AIFA n. 809/15).