Malignant B cells Biology and 3D modelling
Cristina Scielzo
Email: scielzo.cristina@hsr.it
Location: DIBIT1, Floor 3, Room 3
Group leader, Malignant B cells Biology and 3D modelling Unit
Cristina received her doctor degree in Medical Biotechnology at Università Vita- Salute San Raffaele, in the Lab of Prof Caligaris-Cappio and Prof Paolo Ghia. In 2012 she obtained a PhD in Physiology at University of Milano. During these years she focused her research interests on the interplay between leukemic cells and the microenvironment, making important contributions to the field. In 2005, she implemented biochemical studies to the molecular characterization of chronic lymphocytic leukemia (CLL) cells, which led to the identification of HS1 protein as a new prognostic factor. This opened a new line of research focused on the properties of the leukemic cells cytoskeleton and its role in regulating cells interactions with the microenvironment. Thanks to her experience as Visiting Scientist at CNIC in Madrid (Spain), she acquired new skills to optimize imaging techniques.
Since 2020, she is Group Leader at IRCCS Ospedale San Raffaele at the division of Experimental Oncology. Her team is studying the tumour cell/microenvironment interactions in CLL by unravelling HS1 protein mediated cytoskeletal activities. In parallel, they are developing new advanced 3D in vitro co-culture systems by prototyping a bench-top 3D bio-printer. Her research activity is currently supported by AIRC (Associazione Italiana per la ricercar sul cancro) and European Haematology association (EHA). Cristina has published >50 articles in peer-reviewed journals. Her work has been cited > 3500 times, with an H-index of 29.
2012 PhD in Physiology, Università degli Studi di Milano, Italy
2009 Master degree in Biotechnology, Università Vita-Salute San Raffaele, Milan, Italy. This title was obtained in parallel with the research activity.
1997 - 2001 Bachelor degree in Biotechnology, Università degli Studi di Genova, Italy.
July 2020 - present Group Leader – Malignant B cell biology and 3D modelling Unit - Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy
2016– 2019 Project Leader - B cell neoplasia Unit - IRCCS Hospital San Raffale, Milan, Italy
2012 - 2016 Post doc - Laboratory of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy
2011 Visiting Scientist - Microscopy Unit, CNIC (Fundación Centrom Nacional de Investigaciones Cardiovasculares Carlos III), Madrid, Spain
2003 - 2009 Fellow - Laboratory of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan
2003 Visiting fellow - Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston USA
2001 - 2002 Fellow - Cancer Immunology Laboratory, Institute for Cancer Research and Treatment (IRCC), Candiolo, Italy
2010 - 2011 Research Fellowship from European Hematology Association (EHA)
2007 - Award for scientific merits at the “4th International Leukocyte Signal Transduction Workshop: Clinical implications of signaling pathways”, Rhodes, Greece.
2004 - 2006 Fellowship from Italian Association for Cancer Reasearch (AIRC).