Genetics and cell biology
Biomolecular nuclear magnetic resonance
The group uses biomolecular NMR spectroscopy coupled to biochemical, biophysical and computational methods to study the structure/function activity of proteins (or protein domains) involved in human diseases (e.g. cancer, genetic diseases).
Research activity
The unit is interested in:
- the structure, dynamics and activity of chromatin interacting domains (e.g. PHD domains, BRD domains) present in transcriptional regulators involved in cancer and or genetic diseases (e.g. Sp140, NSD1. NSD2);
- identifying small molecules able to inhibit the activity of extracellular receptors or proteins highly expressed in tumours (e.g.avb3 integrin) , in inflammation conditions (e.g. HMGB1), in neurodegenerative disorders (e.g. Prion disease), muscular distrophies (e.g. Dux4)
- biophysical characterization of fuzzy interactions (e.g. HMGB1-CXCL12)
- applying NMR as analytical technique in metabolomics+
