Genomics of renal diseases and hypertension
Our Clinical Research Unit works within the Nephrology and Dialysis Clinical Department of IRCCS Ospedale San Raffaele and mainly deals with kidney diseases, such as hypertension, acute and chronic renal failure, polycystic kidney disease, lupus nephritis, kidney stone disease.
Focus of our projects is essential hypertension, a complex and multifactorial disease studied by different approaches: clinical (24-hour pressure monitoring, sodium sensitivity test, hyposodic diet, pharmacological trials), genomic (characterization of DNA polymorphisms in candidate genes), pharmacogenomic (therapy assignment based on patient's genetic characteristics), humoral biomarkers (endogenous ouabain, hormones, electrolytes) and environmental (lifestyle, sodium control in the diet).
Our goal is to implement a "precision medicine" aimed to identify genetic and haematochemical markers predicting the individual response to a particular treatment (pharmacological, dietary, etc.), protecting from organ complications and/or preventing adverse outcomes (stroke, infarction, acute renal failure).
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Trudu M, Janas S, Lanzani C, Debaix H, Schaeffer C, Ikehata M, Citterio L, Demaretz S, Trevisani F, Ristagno G, Glaudemans B, Laghmanik, Dell’Antonio G, the Swiss Kidney Project on Genes in Hypertension (SKIPOGH) team 11, Loffing J, Rastaldi MG, Manunta P, Devuyst O, Rampoldi L. Common noncoding UMOD promoter variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression. Nat Med. 2013 Dec;19(12):1655-60.
Citterio L, Ferrandi M, Delli Carpini S, Simonini M, Kuznetsova T, Molinari I, Dell'Antonio G, Lanzani C, Merlino L, Brioni E, Staessen JA, Bianchi G, Manunta P. cGMP-Dependent protein kinase 1 polymorphisms underlie renal sodium handling impairment. Hypertension 2013 Dec;62(6):1027-33.
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