Massimo Degano completed his studies in chemistry at the University of Padua under the guidance of Professor Mario Mammi, focusing on the crystal structure of an odorant-binding protein for his thesis. He then pursued further education in the field of structural enzymology, conducting research in the laboratories of Professors James C. Sacchettini and Vern L. Schramm. During this period, he determined the first crystal structure of an enzyme exhibiting nucleoside hydrolase activity. Dr. Degano took a second postdoctoral position in the laboratory of Professor Ian A. Wilson. Here, he devoted his activities to the study of immune system receptors, achieving a milestone by contributing significantly to the elucidation of the first αβ T-cell receptor structure and its interactions with various MHC-peptide ligands. Then, after heading for two years the crystallography and molecular biology area of the Italian synchrotron source ELETTRA, he joined in 2001 the San Raffaele Research Institute. Dr. Degano has a robust background in biochemistry and structural biology, with specialized expertise in utilizing advanced techniques such as X-ray crystallography and other cutting-edge biophysical methods. Collaborating both within the Institute and with external partners, Dr. Degano is actively engaged in projects aimed at unraveling the structural intricacies of macromolecules with relevance to human health, such as lymphomas, autoimmune and infectious diseases.

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