Emerging bacterial pathogens

Nicola Ivan Lorè

Nicola Lorè

Email: lore.nicolaivan@hsr.it
Location: DIBIT2 A4, Floor 2

Project Leader, Emerging bacterial pathogens

I obtained my PhD degree in Genetic and Biomolecular Sciences from the University of Milan in 2012. During my PhD, I defined and characterized new experimental models to dissect opportunistic pathogens/host interaction during acute and chronic airways infections in mouse models. In 2012, I joined as post-doc the Infection and Cystic Fibrosis Unit at the San Raffaele Scientific (OSR) Institute (Milan, Italy). As part of my postdoctoral training, I was a visiting fellow at the Institute Pasteur de Lille (FR), at the Tel Aviv University (IL) and the Wellcome Trust, Centre for Human Genetics (UK). My postdoctoral studies focused on understanding the mechanisms mediating the immune response triggered by respiratory opportunistic pathogens. Today I am a Project Leader working on my independent research program within the Emerging Bacterial Pathogens Unit at DITID-IRCCS Ospedale San Raffaele (OSR) (Milan, Italy).

Brief introduction

My scientific interests focus on the development of novel therapeutic approaches/interventions to modulate host/pathogen response in experimental models (E.g. in vitro, exvivo and in vivo), with a particular attention on chronic respiratory infections and opportunistic pathogens (nontuberculous mycobacteria, NTHi or P. aeruginosa). My research activity has been, or it is supported by national and international grant agency, such Italian Ministry of health, Fondazione Cariplo, Fondazione Italiana Fibrosi cistica, Telethon or US cystic fibrosis foundation.

Research activity

  • Host and pathogens biomarkers using omics technologies to dissect nontuberculous mycobacteria pulmonary diseases: we determine how host transcriptomics profiles, identified by single cell RNA sequencing, or nontuberculous mycobacteria genomic profiles, detected by whole genome sequencing, may by exploited as biomarker for progression in M.abscessuss pulmonary diseases.
  • Host-Bacteria interaction in respiratory infections by spatial transcriptomic: in this project spatial transcriptomic is exploited to dissect how host-bacteria interact in pathological lung tissues.
  • In vivo evaluation of antimicrobial targets against new antimicrobials or therapeutics against nontuberculous mycobacteria: here we will unravel new antimicrobials or new combinatorial treatments may modulate bacterial persistence in mouse model of respiratory infection by M. absccessus
  • Dissect the role of type 17 immunity in respiratory infections by opportunistic pathogens: we want to determine the contribution of type 17 immunity in modulating host defense and immunopathology in chronic respiratory infection by opportunistic, such as in the context of Cystic Fibrosis