
Institutes
Memory disorders

In last few years the increasing of population ageing is associated with an increase of incidence of secondary and primary forms of dementia. Alzheimer’s Disease (AD) is the most frequent form of dementia. The identification of subjects affected by mild cognitive impairment (MCI) with a high risk of conversion into AD is a very important issue for therapeutic strategies. Aim of this unit is to identify early markers of disease to achieve the diagnosis in the early stage of AD studying MCI patients using advanced neuroradiological and neurophysiological techniques and repeated neuropsychological evaluations in order to find elements able to distinguish between those who convert and those who do not convert into AD.
Research activity
Ferrari L, Huang SC, Magnani G, Ambrosi A, Comi G, Leocani L. Optical coherence tomography reveals retinal neuroaxonal thinning in frontotemporal dementia as in Alzheimer's disease. J Alzheimers Dis. 2017;56(3):1101-1107.
Cerami C, Dodich A, Greco L, Iannaccone S, Magnani G, Marcone A, Pelagallo E, Santangelo R, Cappa SF, Perani D. The role of single-subject brain metabolic patterns in the early differential diagnosis of primary progressive aphasias and in prediction of progression to dementia. J Alzheimers Dis. 2017;55(1):183-197.
Mazzeo S, Santangelo R, Bernasconi MP, Cecchetti G, Fiorino A, Pinto P, Passerini G, Falautano M, Comi G, Magnani G. Combining cerebrospinal fluid biomarkers and neuropsychological assessment: A simple and cost-effective algorithm to predict the progression from mild cognitive impairment to Alzheimer's disease dementia. J Alzheimers Dis. 2016 Oct 18;54(4):1495-1508.
Perani D, Cerami C, Caminiti SP, Santangelo R, Coppi E, Ferrari L, Pinto P, Passerini G, Falini A, Iannaccone S, Cappa SF, Comi G, Gianolli L, Magnani G. Cross-validation of biomarkers for the early differential diagnosis and prognosis of dementia in a clinical setting. Eur J Nucl Med Mol Imaging. 2016 Mar;43(3):499-508.
Ballarini T, Iaccarino L, Magnani G, Ayakta N, Miller BL, Jagust WJ, Gorno-Tempini ML, Rabinovici GD, Perani D. Neuropsychiatric subsyndromes and brain metabolic network dysfunctions in early onset Alzheimer's disease. Hum Brain Mapp. 2016 Dec;37(12):4234-424.
Clarelli F, Mascia E, Santangelo R, Mazzeo S, Giacalone G, Galimberti D, Fusco F, Zuffi M, Fenoglio C, Franceschi M, Scarpini E, Forloni G, Magnani G, Comi G, Albani D, Martinelli Boneschi F. Gene and response to cholinesterase inhibitors in an Italian cohort of Alzheimer's disease patients. J Alzheimers Dis. 2016 Apr 16;52(4):1203-8.
Spinelli EG, Caso F, Agosta F, Gambina G, Magnani G, Canu E, Blasi V, Perani D, Comi G, Falini A, Gorno-Tempini ML, Filippi M. A multimodal neuroimaging study of a case of crossed nonfluent/agrammatic primary progressive aphasia. J Neurol. 2015 Oct;262(10):2336-45.
Caso F, Agosta F, Mattavelli D, Migliaccio R, Canu E, Magnani G, Marcone A, Copetti M, Falautano M, Comi G, Falini A, Filippi M. White matter degeneration in atypical Alzheimer disease. Radiology. 2015 Oct;277(1):162-72.
Agosta F, Galantucci S, Magnani G, Marcone A, Martinelli D, Antonietta Volontè M, Riva N, Iannaccone S, Ferraro PM, Caso F, Chiò A, Comi G, Falini A, Filippi M. MRI signatures of the frontotemporal lobar degeneration continuum. Hum Brain Mapp. 2015 Jul;36(7):2602-14.
Santangelo R, Coppi E, Ferrari L, Bernasconi MP, Pinto P, Passerini G, Comi G, Magnani G. Cerebrospinal fluid biomarkers can play a pivotal role in the diagnostic work up of primary progressive aphasia. J Alzheimers Dis. 2015;43(4):1429-40.
Cerami C, Della Rosa PA, Magnani G, Santangelo R, Marcone A, Cappa SF, Perani D. Brain metabolic maps in Mild Cognitive Impairment predict heterogeneity of progression to dementia. Neuroimage Clin. 2014 Dec 5;7:187-94.
Claudia Arcari
Psychologist
Alessandra Barbieri
Psychologist
Maria Paola Bernasconi
Psychologist
Rosalinda Cardamone
Psychologist
Francesca Caso
Neurologist
Giordano Cecchetti
Neurologist
Monica Falautano
Psychologist
Agnese Fiorino
Psychologist
Francesca Possa
Psychologist
Elisa Riboni
Psychologist
Roberto Santangelo
Neurologist