Gene transfer technologies and new gene therapy strategies

Luigi Naldini

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Email: naldini.luigi@hsr.it
Location: DIBIT1 A3, Floor 2, Room 57

Director, San Raffaele Telethon Institute for Gene Therapy
Group leader, Gene transfer technologies and new gene therapy strategies Unit
Group leader, Targeted cancer gene therapy Unit
Full professor, Vita-Salute San Raffaele University

Luigi Naldini, M.D., Ph.D., is Professor of Cell and Tissue Biology and of Gene and Cell Therapy at the San Raffaele University School of Medicine and Scientific Director of the San Raffaele Telethon Institute for Gene Therapy, Milan, Italy.

He has pioneered the development and applications of lentiviral vectors for gene transfer, which have become one of the most widely used tool in biomedical research and, upon recently entering clinical testing, are providing a long sought hope of cure for several currently untreatable and otherwise deadly human diseases. Since then he has continued to investigate new strategies to overcome the major hurdles to safe and effective gene transfer, translate then into new therapeutic strategies for genetic disease and cancer, and allowed new insights into hematopoietic stem cell function, induction of immunological tolerance and tumor angiogenesis. His work also contributed to advance the use of artificial nucleases for targeted genome editing in cell and gene therapy.

He is Member of the European Molecular Biology Organization (EMBO), has been President of the European Society of Gene and Cell Therapy (ESGCT), and has been appointed as expert on the “Human Gene Editing Study” of the US National Academies of Sciences and of Medicine, and on the Italian National Committee for Biosafety, Biotechnology and Life Sciences. He was awarded a European Research Council Advanced Investigator Grant (ERC) in 2009, the Outstanding Achievement Award from the American Society of Gene and Cell Therapy (ASGCT) in 2014 and from ESGCT in 2015, an Honorary doctorate from the Vrije University, Brussel, in 2015, the Jimenez Diaz Prize in 2016, the Beutler Prize from the American Society of Hematology (ASH) in 2017, the LouisJeantet Prize for Medicine, Lausanne, in 2019 and the Global Health Pioneer Award 2019, Dubai. Nominated “Grande Ufficiale” dell’Ordine “Al Merito della Repubblica Italiana”, from the President of the Republic and the Prime Minister of Italy , on December 27th 2019. He has published 278 scientific papers cited >41,000 times. SCOPUS Author hindex : 97