The molecular mechanisms of cellular aging and differentiation, so the field of stem cell and cancer biology have always been my main area of interest and fascination. I have worked on several different aspects of this incredibly broad field. During my PhD training at the European School of Molecular Medicine in Fabrizio d’Adda di Fagagna lab at IFOM (Milan) I investigated the molecular mechanisms by which oncogenes induce DNA damage and cellular senescence. I also focused on the study of alterations of chromatin structure in cancer and on new targeted therapies aimed to re-establish normal epigenetic patterns for cancer treatment. In my postdoctoral training in the lab of Eva Hernando at New York University by using genetic and chemical-based approaches, I identified novel molecular targets involved in the maintenance of stem cell self-renewal capacity, with a particular focus on the epigenetic and transcriptional mechanisms controlling stem cell biology and differentiation in physiological and pathological conditions. During my training in USA, I was awarded prestigious postdoctoral fellowships including an EMBO long-term fellowship, Human Frontier Science Program (HFSP) and a New York Stem Cell Foundation Druckenmiller fellowship (NYSCF). In the fall 2015 I returned to Italy and at the beginning of 2016 I started the activities of my lab at the San Raffaele Telethon Institute for Gene Therapy within Ospedale San Raffaele. My lab aims at dissecting and targeting senescence programs in normal, aged and malignant hematopoiesis.  In 2020 I received the New York Stem Cell Foundation Robertson Investigator Award and I was awarded with an ERC Consolidator Grant.