Experimental oncology
Gynecologic oncology
Realization and definition of clinical trials that regard the treatment of gynecological cancers, with a strong cooperation with MITO (Multicenter Italian Trial in Ovarian cancer and gynecological malignancies) and other international research groups, such as European RAre CAncers, the European Organization for Treatment of Trophoblastic Diseases, the European Network for Gynecological Oncological Trial, the Gynecologic Cancer InterGroup.
Research activity
The clinical research activity is addressed towards:
- Clinical trials in phase II and III for the evaluation of new therapeutical protocols in the medical treatment of gynecological neoplasias
- The study of treatment and prognostic factors of rare gynecological neoplasias
- Fertility preservation
- Quality of life in gynecological oncology
- The role of PET in gynecological tumours
- TCR gene editing in ovarian cancer
- The role of HER2 in trophoblast tumours
- Evaluation of gonadal damage by chemotherapy in murine models
Ray-Coquard I, Trama A, Seckl MJ, Fotopoulou C, Pautier P, Pignata S, Kristensen G, Mangili G, Falconer H, Massuger L, Sehouli J, Pujade-Lauraine E, Lorusso D, Amant F, Rokkones E, Vergote I, Ledermann JA. Rare ovarian tumours: Epidemiology, treatment challenges in and outside a network setting. Eur J Surg Oncol. 2017 Nov 3. pii: S0748-7983(17)30947-2.
Pignata S, Scambia G, Bologna A, Signoriello S, Vergote IB, Wagner U, Lorusso D, Murgia V, Sorio R, Ferrandina G, Sacco C, Cormio G, Breda E, Cinieri S, Natale D, Mangili G, Pisano C, Cecere SC, Di Napoli M, Salutari V, Raspagliesi F, Arenare L, Bergamini A, Bryce J, Daniele G, Piccirillo MC, Gallo C, Perrone FJ. Randomized Controlled Trial Testing the Efficacy of Platinum-Free Interval Prolongation in Advanced Ovarian Cancer: The MITO-8, MaNGO, BGOG-Ov1, AGO-Ovar2.16, ENGOT-Ov1, GCIG Study. Clin Oncol. 2017 Oct 10;35(29):3347-335.
Mangili G, Sigismondi C, Lorusso D, Cormio G, Candiani M, Scarfone G, Mascilini F, Gadducci A, Mosconi AM, Scollo P, Cassani C, Pignata S, Ferrandina G. The role of staging and adjuvant chemotherapy in stage I malignant ovarian germ cell tumors (MOGTs): the MITO-9 study. Ann Oncol. 2017 Feb 1;28(2):333-33.
Bergamini A, Ferrero S, Leone Roberti Maggiore U, Scala C, Pella F, Vellone VG, Petrone M, Rabaiotti E, Cioffi R, Candiani M, Mangili G. Folate receptor alpha antagonists in preclinical and early stage clinical development for the treatment of epithelial ovarian cancer. Expert Opin Investig Drugs. 2016 Dec;25(12):1405-1412.
Mangili G, Ottolina J, Cormio G, Loizzi V, De Iaco P, Pellegrini DA, Candiani M, Giorda G, Scarfone G, Cecere SC, Frigerio L, Gadducci A, Marchetti C, Ferrandina G. Adjuvant chemotherapy does not improve disease-free survival in FIGO stage IC ovarian granulosa cell tumors: The MITO-9 study. Gynecol Oncol. 2016 Nov;143(2):276-280.
Mangili G, Somigliana E, Giorgione V, Martinelli F, Filippi F, Petrella MC, Candiani M, Peccatori F. Fertility preservation in women with borderline ovarian tumours. Cancer Treat Rev. 2016 Sep;49:13-24.
De Marzi P, Bergamini A, Luchini S, Petrone M, Taccagni GL, Mangili G, Colombo G, Candiani M. Hysteroscopic resection in fertility-sparing urgery for atypical hyperplasia and endometrial cancer: safety and efficacy. J Minim Invasive Gynecol. 2015 Nov-Dec;22(7):1178-82.
Bergamini A, Leone Roberti Maggiore U, Ferrero S, Rabaiotti E, Viganò R, Petrone M, De Marzi P, Salvatore S, Candiani M, Mangili G. Investigational therapies currently in Phase II clinical trials for the treatment of pelvic serous carcinomas. Expert Opin Investig Drugs. 2015 Mar;24(3):345-62.
Sigismondi C, Scollo P, Ferrandina G, Candiani M, Angioli R, Viganò R, Scarfone G, Mangili G. Management of bilateral malignant ovarian germ cell tumors: a MITO-9 retrospective study. Int J Gynecol Cancer. 2015 Feb;25(2):203-7.
Mangili G, Lorusso D, Brown J, Pfisterer J, Massuger L, Vaughan M, Ngan HY, Golfier F, Sekharan PK, Charry RC, Poveda A, Kim JW, Xiang Y, Berkowtiz R, Seckl MJ. Trophoblastic disease review for diagnosis and management: a joint report from the International Society for the Study of Trophoblastic Disease, European Organisation for the Treatment of Trophoblastic Disease, and the Gynecologic Cancer InterGroup. Int J Gynecol Cancer. 2014 Nov;24(9 Suppl 3):S109-16.
