Experimental oncology

Lymphoid organ development


Group Leader

Andrea Brendolan


Our research focuses on the biology of nonhematopoietic stromal cells of lymphoid tissues. Stromal cells are emerging as critical organizers of the lymphoid microenvironment, and regulators of tissue homeostasis in health and disease, such as cancer.

Research activity

By combining genetic, molecular and imaging approaches coupled to in vitro 3D culture systems, we aim to decipher how stromal cells:

  • construct the lymphoid microenvironment during embryonic and postnatal development,
  • support survival and progression of hematological and solid tumors,
  • promote tissue remodeling and disease spreading during cancer evolution.

We are also actively translating basic principles of lymphoid organogenesis into development of articial lymphoid organs for pre-clinical applications in cancer and regenerative medicine.