Genetics and cell biology

Protein transport and secretion

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Group leader

Roberto Sitia

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Cells talk to each other by exchanging protein messages. We are interested in understanding how these messages are trasmitted in a language that limits ambiguity, at the right volume and for the right duration.

To answer these questions, we study how protein messages are edited (protein quality control along the secretory pathway), how cells control their voice (proteostasis) and how they make sure that their protein factories are organised in the best way for the needs of the moment  (UPR, redox and KDEL-receptor signaling). Model systems of choice are differentiating B and endometrial cells.

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