Immunology, Transplantation and Infectious diseases



Group leader

Luca Guidotti


Research programs of Immunopathology Unit aim to dissect the cellular and molecular mechanisms responsible for immunopathological responses of the liver, with emphasis on the responses that occur during infection with hepatitis B virus (HBV). HBV is a noncytopathic virus that cause acute and chronic hepatitis of variable duration and severity. Over 250 million people worldwide are chronically infected by HBV and almost a million of them die each year from complications (e.g. cirrhosis and hepatocellular carcinoma, HCC) of this infection.

Research activity

Taking advantage of infected patients, proprietary animal models of infection and new technological advances in the field of static and dynamic imaging, Immunopathology Unit tackles unresolved issues that include the means by which innate and adaptive immune cells traffic and function within the normal, cirrhotic or cancerous livers. This information is and will be used to devise novel immunotherapeutic strategies to cure chronic HBV infection and prevent its life-threatening sequelae.