Innate immunity and tissue remodelling
The innate immune system contributes a first line of defense against pathogens and coordinates the series of events that lead to the healing of damaged tissues. Errors in the interpretation of the signals that the tissue sends to the immune cells are the basis of defective wound healing and play a still poorly defined role in the establishment of autoimmune responses and in the most common pregnancy complications, such as recurrent abortion, preeclampsia and intrauterine growth restriction.
The research group of Patrizia Rovere-Querini has been committed in recent years to the molecular definition of these phenomena. It has contributed to the study of the mechanisms that lead to chronic inflammation, necrosis and regeneration of the skeletal muscle in patients with idiopathic inflammatory myopathies, developing ad hoc experimental models of autoantigen-induced myositis. She has been involved in the identification of early biomarkers of placental damage in cohorts of patients at high risk of pregnancy complications, with specific focus on the role of autoimmunity and of vascular inflammation.
Rovere-Querini P, Canti V, Erra R, Bianchi E, Slaviero G, D'Angelo A, Rosa S, Candiani M, Castiglioni MT. Eculizumab in a pregnant patient with laboratory onset of catastrophic antiphospholipid syndrome: A case report. Medicine (Baltimore). 2018 Oct;97(40):e12584.
Canti V, Del Rosso S, Tonello M, Lucianò R, Hoxha A, Coletto LA, Vaglio Tessitore I, Rosa S, Manfredi AA, Castiglioni MT, Ruffatti A, Rovere-Querini P. Antiphosphatidylserine/prothrombin Antibodies in Antiphospholipid Syndrome with Intrauterine Growth Restriction and Preeclampsia. J Rheumatol. 2018 Aug;45(9):1263-1272.
Sciorati C, Monno A, Doglio MG, Rigamonti E, Ascherman DP, Manfredi AA, Rovere-Querini P. Exacerbation of Murine Experimental Autoimmune Myositis by Toll-Like Receptor 7/8. Arthritis Rheumatol. 2018 Aug;70(8):1276-1287.
Erreni M, Manfredi AA, Garlanda C, Mantovani A, Rovere-Querini P. The long pentraxin PTX3: A prototypical sensor of tissue injury and a regulator of homeostasis. Immunol Rev. 2017 Nov;280(1):112-125
Vezzoli M, Sciorati C, Campana L, Monno A, Doglio MG, Rigamonti E, Corna G, Touvier T, Castiglioni A, Capobianco A, Mantovani A, Manfredi AA, Garlanda C, Rovere-Querini P. The clearance of cell remnants and the regeneration of the injured muscle depend on soluble pattern recognition receptor PTX3. Mol Med. 2016 Nov 23;22: 809–820.
Capobianco A, Cottone L, Monno A, Manfredi AA, Rovere-Querini P. The peritoneum: healing, immunity, and diseases. J Pathol. 2017 Oct;243(2):137-147
Corna G, Caserta I, Monno A, Apostoli P, Manfredi AA, Camaschella C, Rovere-Querini P. The repair of skeletal muscle requires iron recycling through macrophage ferroportin. J Immunol. 2016 Sep 1;197(5):1914-25.
Sciorati C, Rigamonti E, Manfredi AA, Rovere-Querini P. Cell death, clearance and immunity in the skeletal muscle. Cell Death Differ. 2016 Jun;23(6):927-37.
Castiglioni A, Corna G, Rigamonti E, Basso V, Vezzoli M, Monno A, Almada AE, Mondino A, Wagers AJ, Manfredi AA, Rovere-Querini P. FOXP3+ T cells recruited to sites of sterile skeletal muscle injury regulate the fate of satellite cells and guide effective tissue regeneration. PLoS One. 2015 Jun 3;10(6):e0128094.
Sciorati C, Monno A, Ascherman DP, Seletti E, Manfredi AA, Rovere-Querini P. Required role of apoptotic myogenic precursors and toll-like receptor stimulation for the establishment of autoimmune myositis in experimental murine models. Arthritis Rheumatol. 2015 Mar;67(3):809-22.
Campana L, Santarella F, Esposito A, Maugeri N, Rigamonti E, Monno A, Canu T, Del Maschio A, Bianchi ME, Manfredi AA, Rovere-Querini P. Leukocyte HMGB1 is required for vessel remodeling in regenerating muscles. J Immunol. 2014 Jun 1;192(11):5257-6.
Rigamonti E, Touvier T, Clementi E, Manfredi AA, Brunelli S, Rovere-Querini P. Requirement of inducible nitric oxide synthase for skeletal muscle regeneration after acute damage. J Immunol. 2013 Feb 15;190(4):1767-77.
Canti V, Maggio L, Ramirez GA, Locatelli A, Cozzolino S, Ramoni V, Ruffatti A, Tonello M, Valsecchi L, Rosa S, Inversetti A, Manfredi AA, Sabbadini MG, Castiglioni MT, Rovere-Querini P. Hypertension negatively affects the pregnancy outcome in patients with antiphospholipid syndrome. Lupus. 2012 Jun;21(7):810-2.