Immunology, Transplantation and Infectious diseases

Innate immunity and tissue remodelling


Group leader

Patrizia Rovere-Querini


The innate immune system contributes a first line of defense against pathogens and coordinates the series of events that lead to the healing of damaged tissues. Errors in the interpretation of the signals that the tissue sends to the immune cells are the basis of defective wound healing and play a still poorly defined role in the establishment of autoimmune responses and in the most common pregnancy complications, such as recurrent abortion, preeclampsia and intrauterine growth restriction.

Research activity

The research group of Patrizia Rovere-Querini has been committed in recent years to the molecular definition of these phenomena. It has contributed to the study of the mechanisms that lead to chronic inflammation, necrosis and regeneration of the skeletal muscle in patients with idiopathic inflammatory myopathies, developing ad hoc experimental models of autoantigen-induced myositis. She has been involved in the identification of early biomarkers of placental damage in cohorts of patients at high risk of pregnancy complications, with specific focus on the role of autoimmunity and of vascular inflammation.