Immunology, Transplantation and Infectious diseases

Lymphocyte activation

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Head of Unit

Anna Mondino

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The goal is to gain a deeper understanding of the cellular and molecular mechanisms at the basis of adaptive immune responses, with emphasis on the role of T lymphocytes in the establishment of immunological memory and/or peripheral tolerance to tumors. On one side this unit is interested in characterising intracellular events controlling T cell activation and differentiation, on the other researchers wish to characterise T cell behaviour in vivo in mouse models of human diseases. This group have developed tools allowing for the tracing and genetic engineering of antigen-specific CD4+ and CD8+ T cell in physiological and pathological conditions, and defined critical molecular events controlling lymphocyte activation, proliferation and differentiation.

Research activity

Recently the group has been focusing on the role of mTOR, STAT3 and Sin3A in T helper cell differentiation and in STAT3-driven transformation and on the definition of novel adoptive T cell therapy strategies based on engineered T cells and tumor-stroma targeting for the cure of prostate cancer. Results of this research activity are expected to contribute new knowledge in the events dictating protective immunity and to lead to the development of novel immunotherapeutic strategies suitable of clinical translation.