Neuroscience
Eye repair lab
Research focus of this lab are the molecular and cellular mechanisms controlling inflammation in highly prevalent ocular surface disorders (such as: keratitis, conjunctivitis, ocular surface burns, etc.). Specifically, we are trying to better understand the role of corneal nerves in maintaining ocular surface integrity and inflammation-associated nerve alterations.
Our final aim is to apply knowledge generated from these basic mechanisms to improve understanding, and eventually treatment, of disabling, poorly treated ocular disorders.
Bignami F, Lorusso A, Rama P, Ferrari G. Growth inhibition of formed corneal neovascularization following Fosaprepitant treatment. Acta Ophthalmol. 2017 Nov;95(7):e641-e648.
Bignami F, Rama P, Ferrari G. Substance P and its inhibition in ocular inflammation. Curr Drug Targets. 2016;17(11):1265-74.
Ferrari G, Giacomini C, Bignami F, Moi D, Ranghetti A, Doglioni C, Naldini L, Rama P, Mazzieri R. Angiopoietin 2 expression in the cornea and its control of corneal neovascularisation. J Ophthalmol. 2016 Jul;100(7):1005-1010.
Rabiolo A, Bignami F, Rama P, Ferrari G. VesselJ: A new tool for semiautomatic measurement of corneal neovascularization. Invest Ophthalmol Vis Sci. 2015 Dec;56(13):8199-206.
Ferrari G, Rabiolo A, Bignami F, Sizzano F, Palini A, Villa C, Rama P. Quantifying ocular surface inflammation and correlating it with inflammatory cell infiltration in vivo: a novel method. Invest Ophthalmol Vis Sci. 2015 Nov;56(12):7067-75.
Ferrari G, Bignami F, Rama P. Tumor necrosis factor-α inhibitors as a treatment of corneal hemangiogenesis and lymphangiogenesis. Eye Contact Lens. 2015 Mar;41(2):72-6.
Bignami F, Giacomini C, Lorusso A, Aramini A, Rama P, Ferrari G. NK1 receptor antagonists as a new treatment for corneal neovascularization. Invest Ophthalmol Vis Sci. 2014 Sep 16;55(10):6783-94.
Ferrari G, Bignami F, Giacomini C, Capitolo E, Comi G, Chaabane L, Rama P. Ocular surface injury induces inflammation in the brain: in vivo and ex vivo evidence of a corneal-trigeminal axis. Invest Ophthalmol Vis Sci. 2014 Aug 21;55(10):6289-300.
Giacomini C, Ferrari G, Bignami F, Rama P. Alkali burn versus suture-induced corneal neovascularization in C57BL/6 mice: an overview of two common animal models of corneal neovascularization. Exp Eye Res. 2014 Apr;121:1-4.
Ferrari G, Bignami F, Giacomini C, Franchini S, Rama P. Safety and efficacy of topical infliximab in a mouse model of ocular surface scarring. Invest Ophthalmol Vis Sci. 2013 Mar 1;54(3):1680-8.
