Neuroscience
Neuroepigenetics
Throughout life, specialized cells emerge to ensure the proper functioning of tissues and organs. Chromatin represents an intricate assembly of proteins, RNA, and DNA, that constitutes the physiological state of the genome. Epigenetic regulation of chromatin plays a key role in developmental transitions and cell functionality. Unfortunately, various diseases, including genetic syndromes and many tumors, hijack this regulation for pathological purposes. Despite significant progress in decoding epigenetics, we still lack a comprehensive understanding of the hierarchy and molecular logic governing the use of specialized DNA regions. This is even more true in the neural lineage, where complex gene programs to define highly specialized functions, are in place.
Research activity
The Sessa Lab, a young and dynamic group, focuses on ambitious research programs at the intersection of developmental, cell, and molecular biology, with a primary emphasis on epigenetic regulation. Our work revolves around two key areas:
1. Rare Neurological Diseases: We aim to model, investigate, and potentially treat rare neurological diseases driven by epigenetic dysregulation. These diseases are often overlooked but hold valuable insights into pathological and physiological mechanisms. Our research primarily involves utilizing human induced pluripotent stem cells (hiPSCs) and genetically modified mouse models.
2. Neuro-Oncology: In the realm of brain cancer research, we pursue biotechnological strategies to identify and exploit tumor vulnerabilities, ultimately impeding cancer progression. We focus on designing and validating synthetic factors with anti-tumor activity, leveraging natural epigenetic functions tailored against specific targets to inhibit the tumorigenic potential of cancer cells.
Through our research activities, we generate experimental models for human diseases, especially rare syndromes, and develop innovative approaches against brain cancer. Our ultimate goal is to advance our understanding of epigenetic regulation and translate it into meaningful medical applications.
