Oncological and regenerative neurosurgery
The Neurosurgery Department provides comprehensive services for the diagnosis, treatment and surgical management of the main conditions affecting the central and peripheral nervous system (including brain and spinal cord). The Department is an internationally-recognized centre for skull base tumors treatment (pituitary adenomas, meningiomas, chordomas) performing microsurgery as well as Gamma Knife Stereotactic Radiosurgery. The multidisciplinary team composed by neurosurgeons, endocrinologists, neuroradiologists, neuro-ophthalmologists, maxillofacial surgeons and radiotherapists ensure the best and up-to-date approach to these pathologies.
In the research field the team is mainly focusing on neuro-endocrinological disorders; introduction of new surgical techniques for skull-base surgery; use of highly advanced technologies as functional MRI; use of neuro-navigator and cortical stimulator, 3 tesla MRI and deep brain stimulation. Basic research on the neurooncology field is studying the molecular characterization of cancer-stem-cells in human glioblastoma. Another topic of research is genomics and molecular biology on brain tumors (in cooperation with the Max Planck Institut). The Unit has recently started a project for the set-up of a tissue biobank of brain tumors.
Barzaghi LR, Donofrio, CA, Panni P, Losa M, Mortini P. Treatment of empty sella associated with visual impairment: a systematic review of chiasmapexy techniques. Pituitary 2018 Feb;21(1):98-106.
Mortini P, Barzaghi LR, Albano L, Panni P, Losa M. Microsurgical therapy of pituitary adenomas. Endocrine 2018 Jan;59(1):72-81.
Casanueva FF, Barkan AL, Buchfelder M, Klibanski A, Laws ER, Loeffler JS, Melmed S, Mortini P, Wass J, Giustina A. Criteria for the definition of Pituitary Tumor Centers of Excellence (PTCOE): A Pituitary Society Statement, Pituitary 2017 Oct;20(5):489-498.
Della-Torre E, Campochiaro C, Cassione EB, Albano L, Gerevini S, Bianchi-Marzoli S, Bozzolo E, Passerini G, Lanzillotta M, Terreni M, Callea M, Trimarchi M, Mortini P, Tresoldi M, Acerno S, Dagna L. Intrathecal rituximab for IgG4-related hypertrophic pachymeningitis. J Neurol Neurosurg Psychiatry. 2017 doi:10.1136/jnnp-2017-316519.
Spina A, Boari N, Gagliardi F, Bailo M, Morselli C, Iannaccone S, Mortini P. The emerging role of gamma knife radiosurgery in the management of glossopharyngeal neuralgia. Neurosurgical Review 2017 Jul 26. doi: 10.1007/s10143-017-0886-0.
Losa M, Spatola G, Albano L, Gandolfi A, Del Vecchio A, Bolognesi A, Mortini, P. Frequency, pattern, and outcome of recurrences after gamma knife radiosurgery for pituitary adenomas. Endocrine 2017 Jun;56(3):595-602.
Snider S, Cavalli A, Colombo F, Sannino A, Mortini P. A novel composite type I collagen scaffold with micropatterned porosity regulates the entrance of phagocytes in a severe model of spinal cord injury. Journal of Biomedical Materials Research - Part B Applied Biomaterials 2017 Jul;105(5):1040-1053.
Barzaghi LR, Spina A, Gagliardi F, Boari N, Mortini P. Trans-Frontal-Sinus-Subcranial Approach to Olfactory Groove Meningiomas: Surgical Results, Clinical and Functional Outcome in A Consecutive Series of 21 Patients. World Neurosurg. 2017 May;101:315-324.
Gagliardi F, Narayanan A, Mortini P. SPARCL1 a novel player in cancer biology. Critical Reviews in Oncology/Hematology 2017 Jan;109:63-68.
Franzin A, Panni P, Spatola G, Vecchio AD, Gallotti AL, Gigliotti CR, Cavalli A, Donofrio CA, Mortini P. Results of volume-staged fractionated Gamma Knife radiosurgery for large complex arteriovenous malformations: obliteration rates and clinical outcomes of an evolving treatment paradigm. J Neurosurg. 2016 Dec;125(Suppl 1):104-113.
Lina Raffaella Barzaghi
Jody Filippo Capitanio
Camillo Ferrari da Passano
MD, PhD, Neurosurgeon
MD, PhD, Neurosurgeon