San Raffaele Telethon Institute for Gene Therapy

Retrovirus-host interactions and innate immunity to gene transfer


Group Leader

Anna Kajaste-Rudnitski


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The Unit studies the molecular mechanisms of host-vector interplay and innate immunity in the context hematopoietic stem cell (HSC) gene therapy, with particular focus on innate restriction blocks and host responses potentially triggered by the lentiviral vectors used to convey the therapeutic gene into cells. This group is also interested in studying these pathways in the context of pathological conditions of the central nervous systems and autoimmune diseases. Overall, the aim is to provide insight into how pathogen recognition and consequent innate immune signalling may affect human HSC and hematopoietic development in vivo, with potential broad range clinical impact in the field of gene therapy as well as to shed light on how these same pathways may contribute to autoimmune and inflammatory pathologies.