We are a newly established area working in the rapidly expanding field of immunogenomics. Our unit uses multi-omics strategies to investigate the basis of immune-mediated disease. Current activities focus on prediction of T-cell antigens, study of immune correlates via single-cell and bulk gene expression and epigenetic perturbations, and analysis of gut microbial communities using 16S rRNA sequencing data.
- Single cell-transcriptomics to identify leukemia-intrinsic and -extrinsic correlates of immune escape and post-transplantation relapse
- Generation of a comprehensive framework to map patient-specific interactions between immune system and leukemia (relapsograms)
- High resolution tumor and immune cell profiling of liver metastases that arise from colorectal and pancreatic ductal adenocarcinomas, as part of the grant Associazione Italiana Ricerca sul Cancro (AIRC) 5 per Mille project: “Advanced Immune Gene and Cell Therapies for Liver Metastases”.
- Study of the role of HLA immunogenetics in COVID-19 clinical heterogeneity
- Analysis of the immunogenicity of cancer drug-resistance mutations as part of the "Schottlander Innovation Award high-risk/high-gain pilot projects" to The Institute of Cancer Research from The Schottlander Research Charitable Trust
- Analysis of the gut microbiome in leukemia