Omics Sciences

Immunogenomics Lab

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Area coordinator

Marco Punta

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We use multi-omics strategies to investigate the interactions between cancer and the immune microenvironment, with a particular focus on immune escape mechanisms in hematological malignancies following allogeneic hematopoietic cell transplantation (allo-HCT). Our research is conducted in close collaboration with biologists, clinicians, computational biologists, and mathematicians.

Research activity

  • Using omics technologies (bulk and single-cell transcriptomics, spatial proteomics, epigenomics, metabolomics) to identify leukemia-intrinsic and -extrinsic correlates of immune escape and post-transplant relapse in acute myeloid leukemia
  • Investigating aberrant splicing as a putative novel mechanism of immune escape in acute myeloid leukemia post allo-HCT.
  • Leveraging high-dimensional flow cytometry and CITE-seq technologies for characterizing the immune microenvironment in hepatic colorectal cancer metastases
  • Investigating minor and cancer-specific antigens (e.g., those derived from aberrantly expressed human retroelements) as potential targets for novel immunotherapies.
  • Benchmarking cell type deconvolution methods applied to bulk RNA sequencing data of bone marrow samples