Omics Sciences
Immunogenomics Lab
We use multi-omics strategies to investigate the interactions between cancer and the immune microenvironment, with a particular focus on immune escape mechanisms in hematological malignancies following allogeneic hematopoietic cell transplantation (allo-HCT). Our research is conducted in close collaboration with biologists, clinicians, computational biologists, and mathematicians.
Research activity
- Using omics technologies (bulk and single-cell transcriptomics, spatial proteomics, epigenomics, metabolomics) to identify leukemia-intrinsic and -extrinsic correlates of immune escape and post-transplant relapse in acute myeloid leukemia
- Investigating aberrant splicing as a putative novel mechanism of immune escape in acute myeloid leukemia post allo-HCT.
- Leveraging high-dimensional flow cytometry and CITE-seq technologies for characterizing the immune microenvironment in hepatic colorectal cancer metastases
- Investigating minor and cancer-specific antigens (e.g., those derived from aberrantly expressed human retroelements) as potential targets for novel immunotherapies.
- Benchmarking cell type deconvolution methods applied to bulk RNA sequencing data of bone marrow samples
