Prof. Dr. Hana Algül
Technische Universität München, Munich

Prof. Dr. Dirk Busch
Technische Universität München, Munich

Dr. Luca Gianni
Gianni Bonadonna Foundation, Milan

Prof. Francesco Sclafani (since February 2023)
Institut Jules Bordet, Brussels

Prof. Nicola Valeri (former)
The Institute of Cancer Research, London
Imperial College London, London​

 

The program gather together 5 clinical units of IRCCS Ospedale San Raffaele:

• Hepatobiliary surgery - Head: Luca Aldrighetti
• Anatomic pathology and histopathology - Head: Claudio Doglioni
• Pancreatic surgery - Head: Massimo Falconi
• Oncology - Head of pancreatic oncology: Michele Reni
• Diagnostic imaging – Head: Francesco De Cobelli

Crippa S, Malleo G, Langella S, Ricci C, Casciani F, Belfiori G, Galati S, Ingaldi C, Lionetto G, Ferrero A, Casadei R, Ercolani G, Salvia R, Falconi M, Cucchetti A. Cure Probabilities After Resection Of Pancreatic Ductal Adenocarcinoma: A Multi-Institutional Analysis Of 2554 Patients. Ann Surg. 2023 Dec 4. doi: 10.1097/SLA.0000000000006166. 

Manfredi F, Stasi L, Buonanno S, Marzuttini F, Noviello M, Mastaglio S, Abbati D, Potenza A, Balestrieri C, Cianciotti BC, Tassi E, Feola S, Toffalori C, Punta M, Magnani Z, Camisa B, Tiziano E, Lupo-Stanghellini MT, Branca RM, Lehtiö J, Sikanen TM, Haapala MJ, Cerullo V, Casucci M, Vago L, Ciceri F, Bonini C, Ruggiero E. Harnessing T cell exhaustion and trogocytosis to isolate patient-derived tumor-specific TCR. Sci Adv. 2023 Dec;9(48):eadg8014. doi: 10.1126/sciadv.adg8014.

Alarcon JF, Soliman M, Ludtke T, Clemente E, Dobricic M,  Violatto MB, Corbelli A, Fiordaliso F, Cordiglieri C, Laura Talamini, Sitia G,  Moya S, Bigini Pand Monopoli MP. Long-term retention of gold nanoparticles in the liver is not affected by their physicochemical characteristics. Nanoscale. 2023 Apr 25.

Violatto MB, Sitia G, Talamini L, Morelli M, Lan Tran N, Zhang Q, Masood A, Pelaz B, Chakraborty I, Cui D, Parak WJ, Salmona M, Bastús NG,  Puntes V and Bigini P. Variations in Biodistribution and Acute Response of Differently Shaped Titania Nanoparticles in Healthy Rodents. Nanomaterials 2023, 13, 1174.

Kerzel T, Giacca G, Beretta S, Bresesti C, Notaro M, Scotti GM, Balestrieri C, Canu T, Redegalli M, Pedica F, Genua M, Ostuni R, Kajaste-Rudnitski A, Oshima M, Tonon G, Merelli I, Aldrighetti L, Dellabona P, Coltella N, Doglioni C, Rancoita PMV, Sanvito F, Naldini L, Squadrito ML. In vivo macrophage engineering reshapes the tumor microenvironment leading to eradication of liver metastases. Cancer Cell. 2023 Nov 13;41(11):1892-1910.e10. doi: 10.1016/j.ccell.2023.09.014. 

Monieri M, Rainone P, Sacchi A, Gori A, Gasparri AM, Coliva A, Citro A, Ferrara B, Policardi M, Valtorta S, Pocaterra A, Alfano M, Sheppard D, Piemonti L, Moresco RM, Corti A*, Curnis F*. A stapled chromogranin A-derived peptide homes in on tumors that express αvβ6 or αvβ8 integrins. Int J Biol Sci. 2023; 19(1):156-166. doi:10.7150/ijbs.76148. (*Corresponding Authors)

Caronni N, La Terza F, Vittoria FM, Barbiera G, Mezzanzanica L, Cuzzola V, Barresi S, Pellegatta M, Canevazzi P, Dunsmore G, Leonardi C, Montaldo E, Lusito E, Dugnani E, Citro A, Ng MSF, Schiavo Lena M, Drago D, Andolfo A, Brugiapaglia S, Scagliotti A, Mortellaro A, Corbo V, Liu Z, Mondino A, Dellabona P, Piemonti L, Taveggia C, Doglioni C, Cappello P, Novelli F, Iannacone M, Ng LG, Ginhoux F, Crippa S, Falconi M, Bonini C, Naldini L, Genua M, Ostuni R. IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer. Nature. 2023 Nov;623(7986):415-422. doi: 10.1038/s41586-023-06685-2.

Tassi E, Bergamini A, Wignall J, Sant'Angelo M, Brunetto E, Balestrieri C, Redegalli M, Potenza A, Abbati D, Manfredi F, Cangi MG, Magliacane G, Scalisi F, Ruggiero E, Maffia MC, Trippitelli F, Rabaiotti E, Cioffi R, Bocciolone L, Candotti G, Candiani M, Taccagni G, Schultes B, Doglioni C, Mangili G, Bonini C. Epithelial ovarian cancer is infiltrated by activated effector T cells co-expressing CD39, PD-1, TIM-3, CD137 and interacting with cancer cells and myeloid cells. Front Immunol. 2023 Oct 4;14:1212444. doi: 10.3389/fimmu.2023.1212444. 

Raccosta L, Marinozzi M, Costantini S, Daniela Maggioni, Ferreira LM, Corna G, Zordan P, Sorice A, Farinello D, Bianchessi S, Riba M, Lazarevic D, Provero P, Mack M, Bondanza A, Nalvarte I,  Gustafsson J-A, Ranzani V, De Sanctis F, Ugel S, Baron S, Lobaccaro J- A, Pontini L, Pacciarini M, Traversari C, Pagani M, Bronte V, Sitia G, Antonson P, Brendolan A, Budillon A & Russo V.  Harnessing the reverse cholesterol transport pathway to favor differentiation of monocyte-derived APCs and antitumor responses. Cell Death Dis. 14, 129 (2023).

Potenza A*, Balestrieri C*, Spiga M, Albarello L, Pedica F, Manfredi F, Cianciotti BC, De Lalla C, Botrugno OA, Faccani C, Stasi L, Tassi E, Bonfiglio S, Scotti GM, Redegalli M, Biancolini D, Camisa B, Elena Tiziano, Sirini C, Casucci M, Iozzi C, Abbati D, Simeoni F, Lazarevic D, Elmore U, Fiorentini G, Di Lullo G, Casorati G, Doglioni D, Tonon G, Dellabona P, Rosati R, Aldrighetti L, Ruggiero E^ and Bonini C^ (*= equal contribution, ^=co-last author). Revealing and harnessing CD39 for the treatment of colorectal cancer and liver metastases by engineered T cells. Gut. 2023 Oct;72(10):1887-1903. doi: 10.1136/gutjnl-2022-328042. 

Bonini C, Chapuis AG, Hudecek M, Guedan S, Magnani C, Qasim W. Genome Editing in Engineered T Cells for Cancer Immunotherapy. Hum Gene Ther. 2023 Sep;34(17-18):853-869. doi: 10.1089/hum.2023.128. 

De Monte L, Clemente F, Ruggiero E, Pini R, Ceraolo MG, Schiavo Lena M, Balestrieri C, Lazarevic D, Belfiori G, Crippa S, Balzano G, Falconi M, Doglioni C, Bonini C, Reni M, Protti MP. Pro-tumor Tfh2 cells induce detrimental IgG4 production and PGE2-dependent IgE inhibition in pancreatic cancer. EBioMedicine. 2023 Sep 28;97:104819. doi: 10.1016/j.ebiom.2023.104819.

Reni M, Peretti U, Macchini M, Orsi G, Militello A, Briccolani A, Falconi M, Cascinu S. Cyclophosphamide maintenance to extend combination chemotherapy-free interval in metastatic pancreatic ductal adenocarcinoma. Dig Liver Dis. 2023 Aug 14:S1590-8658(23)00784-3. doi: 10.1016/j.dld.2023.07.033.

Delfanti G, Dellabona P, Casorati G.  Primary Mouse Invariant Natural Killer T (iNKT) Cell Purification and Transduction. Bio Protoc. 2023 Jul 5;13(13):e4707. doi: 10.21769/BioProtoc.4707.

Tassi E, Noviello M, De Simone P, Lupo-Stanghellini MT, Doglio M, Serio F, Abbati D, Beretta V, Valtolina V, Oliveira G, Racca S, Campodonico E, Ruggiero E, Clerici D, Giglio F, Lorentino F, Dvir R, Xue E, Farina F, Oltolini C, Manfredi F, Vago L, Corti C, Bernardi M, Clementi M, Brix L, Ciceri F, Peccatori J, Greco R, Bonini C. Cytomegalovirus-specific T cells restricted for shared and donor human leukocyte antigens differentially impact on cytomegalovirus reactivation risk after allogeneic hematopoietic stem cell transplantation. Haematologica. 2023 Jun 1;108(6):1530-1543. doi: 10.3324/haematol.2022.280685. 

Barouni RM, Ostuni R. Charting granulopoietic disturbances in sepsis. Nat Immunol. 2023 May;24(5):746-748. doi: 10.1038/s41590-023-01495-0.

Fumagalli V, Di Lucia P, Ravà M, Marotta D, Bono E, Grassi S, Donnici L, Cannalire R, Stefanelli I, Ferraro A, Esposito F, Pariani E, Inverso D, Montesano C, Delbue S, Perlman S, Tramontano E, De Francesco R, Summa V, Guidotti LG, Iannacone M. Nirmatrelvir treatment of SARS-CoV-2-infected mice blunts antiviral adaptive immune responses.  EMBO Mol Med. 2023 May 8;15(5):e17580. doi: 10.15252/emmm.202317580.

Marino R, Tudisco A, Ratti F, Pedica F, Aldrighetti L. Total portal vein replacement with peritoneal interposition graft during Whipple's procedure for extrahepatic cholangiocarcinoma: a technical report. World J Surg Oncol.  2023 Mar 29;21(1):117. doi: 10.1186/s12957-023-02995-x. 

Giglio F, Campodonico E, Lorentino F, Noviello M, Xue E, Greco R, Lazzari L, Bruno A, Lupo Stanghellini MT, Carrabba MG, La Starza R, Casucci M, Bonini C, Chiaretti S, Peccatori J, Foà R, Ciceri F. Case report: Ponatinib as a bridge to CAR-T cells and subsequent maintenance in a patient with relapsed/refractory Philadelphia-like acute lymphoblastic leukemia. Front Oncol. 2023 Jan 10;12:1100105. doi: 10.3389/fonc.2022.1100105. eCollection 2022.

Corti A, Anderluzzi G, Curnis F. Neuropilin-1 and Integrins as Receptors for Chromogranin A-Derived Peptides. Pharmaceutics. 2022 Dec; 14(12): 2555. doi: 10.3390/pharmaceutics14122555.

Smole A, Benton A, Poussin MA, Eiva MA, Mezzanotte C, Camisa B, Greco B, Sharma P, Minutolo NG, Gray F, Bear AS, Baroja ML, Cummins C, Xu C, Sanvito F, Goldgewicht AL, Blanchard T, Rodriguez-Garcia A, Klichinsky M, Bonini C, June CH, Posey AD Jr, Linette GP, Carreno BM, Casucci M, Powell DJ Jr. Expression of inducible factors reprograms CAR-T cells for enhanced function and safety. Cancer Cell. 2022 Dec 12;40(12):1470-1487.e7.

Alvisi G, Termanini A, Soldani C, Portale F, Carriero R, Pilipow K, Costa G, Polidoro M, Franceschini B, Malenica I, Puccio S, Lise V, Galletti G, Zanon V, Colombo FS, De Simone G, Tufano M, Aghemo A, Di Tommaso L, Peano C, Cibella J, Iannacone M, Roychoudhuri R, Manzo T, Donadon M, Torzilli G, Kunderfranco P, Di Mitri D, Lugli E, Lleo A. Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defines hyperactivated Tregs as a potential therapeutic target. J Hepatol. 2022 Nov;77(5):1359-1372.

Tran NL*, Ferreira LM*, Alvarez-Moya B*, Buttiglione V, Ferrini B, Zordan P, Monestiroli A, Fagioli C, Bezzecchi E, Scotti GM, Esposito A, Leone R, Gnasso C, Brendolan A, Guidotti LG, Sitia G. Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier. Elife. 2022 Oct 25;11:e80690. doi: 10.7554/eLife.80690. (* equal contribution)

Montaldo E, Lusito E, Bianchessi V, Caronni N, Scala S, Basso-Ricci L, Cantaffa C, Masserdotti A, Barilaro M, Barresi S, Genua M, Vittoria FM, Barbiera G, Lazarevic D, Messina C, Xue E, Marktel S, Tresoldi C, Milani R, Ronchi P, Gattillo S, Santoleri L, Di Micco R, Ditadi A, Belfiori G, Aleotti F, Naldini MM, Gentner B, Gardiman E, Tamassia N, Cassatella MA, Hidalgo A, Kwok I, Ng LG, Crippa S, Falconi M, Pettinella F, Scapini P, Naldini L, Ciceri F, Aiuti A, Ostuni R. Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress. Nat Immunol. 2022 Oct;23(10):1470-1483. doi: 10.1038/s41590-022-01311-1.

Ferrara B, Dugnani E, Sordi V, Pasquale V, Pellegrini S, Reni M, Balzano G, Piemonti L. A Comprehensive Characterization of Stemness in Cell Lines and Primary Cells of Pancreatic Ductal Adenocarcinoma. Int J Mol Sci. 2022 Sep 14;23(18):10663. doi: 10.3390/ijms231810663.

Delfanti G, Cortesi F, Perini A, Antonini G, Azzimonti L, de Lalla C, Garavaglia C, Squadrito ML, Fedeli M, Consonni M, Sesana S, Re F, Shen H, Dellabona P, Casorati G. TCR-engineered iNKT cells induce robust antitumor response by dual targeting cancer and suppressive myeloid cells.  Sci Immunol. 2022 Aug 12;7(74):eabn6563. doi: 10.1126/sciimmunol.abn6563.

Corti A, Calimeri T, Curnis F, Ferreri AJM. Targeting the Blood-Brain Tumor Barrier with Tumor Necrosis Factor-α. Pharmaceutics. 2022 Jul 6;14(7):1414. doi: 10.3390/pharmaceutics14071414.

Arcangeli S, Bove C, Mezzanotte C, Camisa B, Falcone L, Manfredi F, Bezzecchi E, El Khoury R, Norata R, Sanvito F, Ponzoni M, Greco B, Moresco MA, Carrabba MG, Ciceri F, Bonini C, Bondanza A, Casucci M. CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome. J Clin Invest. 2022 Jun 15;132(12):e150807.

Faccani C, Rotta G, Clemente F, Fedeli M,  Abbati D, Manfredi F, Potenza A, Anselmo A, Pedica F, Fiorentini G, Villa C, Protti MP, Doglioni C, Aldrighetti L, Bonini C, Casorati G, Dellabona P, de Lalla C. Workflow for high-dimensional flow cytometry analysis of T cells from tumor metastases. Life Science Alliance. Jun 2022, 5 (10) e202101316. doi: 10.26508/lsa.202101316. 

Caronni N, Ostuni R. Drugging inflammation: Easier NSAID than done. Immunity. 2022 Jun 14;55(6):973-975. doi: 10.1016/j.immuni.2022.05.009. 

Konjar Š, Ficht X, Iannacone M, Veldhoen M. Heterogeneity of tissue resident memory T cells. Immunol Lett. 2022 May;245:1-7.

Iannacone M, Andreata F, Guidotti LG. Immunological insights in the treatment of chronic hepatitis B. Curr Opin Immunol. 2022 May 16;77:102207. doi: 10.1016/j.coi.2022.102207.

Sitia G, Fiordaliso F, Violatto MB, Alarcon JF, Talamini L, Corbelli A, Ferreira LM, Tran NL, Chakraborty I, Salmona M, Parak WJ, Diomede L, Bigini P. Food-Grade Titanium Dioxide Induces Toxicity in the Nematode Caenorhabditis elegans and Acute Hepatic and Pulmonary Responses in Mice. Nanomaterials (Basel). 2022 May 13;12(10):1669. doi: 10.3390/nano12101669.

Delfanti G, Dellabona P, Casorati G, Fedeli M. Adoptive Immunotherapy With Engineered iNKT Cells to Target Cancer Cells and the Suppressive Microenvironment. Front Med (Lausanne). 2022 May 9;9:897750. doi: 10.3389/fmed.2022.897750.

Kuka M, Iannacone M. Heterogeneity in antiviral B cell responses: Lessons from the movies. Immunol Rev. 2022 Mar;306(1):224-233.

Fumagalli V, Venzin V, Di Lucia P, Moalli F, Ficht X, Ambrosi G, Giustini L, Andreata F, Grillo M, Magini D, Ravà M, Friedrich C, Fontenot JD, Bousso P, Gilmore SA, Khan S, Baca M, Vivier E, Gasteiger G, Kuka M, Guidotti LG†, Iannacone M†. Group 1 ILCs regulate T cell-mediated liver immunopathology by controlling local IL-2 availability. Sci Immunol. 2022 Feb 25;7(68):eabi6112. doi: 10.1126/sciimmunol.abi6112. (†Co-Last Authors)

Aiolfi R*, Sitia G*,  Iannacone M, Brunetta I, Guidotti LG, Ruggeri ZM. Arenaviral infection causes bleeding in mice due to reduced serotonin release from platelets. Science Signaling 2022 Feb 22;15(722):eabb0384. doi: 10.1126/scisignal.abb0384. (*equal contribution)

Ruggiero E, Carnevale E, Prodeus A, Magnani ZI, Camisa B, Merelli I, Politano C, Stasi L, Potenza A, Cianciotti BC, Manfredi F, Di Bono M, Vago L, Tassara M, Mastaglio S, Ponzoni M, Francesca Sanvito, Liu D, Balwani I, Galli R, Genua M, Ostuni R, Doglio M, O'Connell D, Dutta I, Yazinski SA, McKee M, Arredouani MS, Schultes B, Ciceri F, Bonini C. CRISPR-based gene disruption and integration of high-avidity, WT1-specific T cell receptors improve anti-tumor T cell function. Sci Transl Med. 2022 Feb 9;14(631):eabg8027. doi: 10.1126/scitranslmed.abg8027.

Pocaterra A, Catucci M, and Mondino A. Adoptive T cell therapy of solid tumors: time to team up with immunogenic chemo/radiotherapy. Curr Opin Immunol. 2022 Feb;74:53-59. doi: 10.1016/j.coi.2021.10.004.

De Sanctis F, Lamolinara A, Boschi F, Musiu C, Caligola S, Trovato R, Fiore A, Frusteri C, Anselmi C, Poffe O, Cestari T, Canè S, Sartoris S, Giugno R, Del Rosario G, Zappacosta B, Del Pizzo F, Fassan M, Dugnani E, Piemonti L, Bottani E, Decimo I, Paiella S, Salvia R, Lawlor RT, Corbo V, Park Y, Tuveson DA, Bassi C, Scarpa A, Iezzi M, Ugel S, Bronte V. Interrupting the nitrosative stress fuels tumor-specific cytotoxic T lymphocytes in pancreatic cancer. J Immunother Cancer. 2022 Jan;10(1):e003549. doi: 10.1136/jitc-2021-003549.

Greco B, Malacarne V, De Girardi F, Scotti GM, Manfredi F, Angelino E, Sirini C, Camisa B, Falcone L, Moresco MA, Paolella K, Di Bono M, Norata R, Sanvito F, Arcangeli S, Doglioni C, Ciceri F, Bonini C, Graziani A, Bondanza A, Casucci M. Disrupting N-glycan expression on tumor cells boosts chimeric antigen receptor T cell efficacy 1 against solid malignancies. Sci Transl Med. 2022 Jan 19;14(628):eabg3072.. doi: 10.1126/scitranslmed.abg3072.

Fumagalli V, Ravà M, Marotta D, Di Lucia P, Laura C, Sala E, Grillo M, Bono E, Giustini L, Perucchini C, Mainetti M, Sessa A, Garcia-Manteiga JM, Donnici L, Manganaro L, Delbue S, Broccoli V, De Francesco R, D'Adamo P, Kuka M, Guidotti LG†, Iannacone M†.  Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion. Sci Immunol. 2021 Nov 23:eabl9929. doi: 10.1126/sciimmunol.abl9929. (†Co-Last Authors)

Tedesco M, Giannese F, Lazarević D, Giansanti V, Rosano D, Monzani S, Catalano I, Grassi E, Zanella ER, Botrugno OA, Morelli L, Panina Bordignon P, Caravagna G, Bertotti A, Martino G, Aldrighetti L, Pasqualato S, Trusolino L, Cittaro D, Tonon G. Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin. Nat Biotechnol. 2021 Oct 11.doi: 10.1038/s41587-021-01031-1.

Greco R, Lorentino F, Albanese S, Stanghellini MTL, Giglio F, Piemontese S, Clerici D, Lazzari L, Marcatti M, Mastaglio S, Xue E, Farina F, Pavesi F, Assanelli A, Carrabba MG, Marktel S, Vago L, Bonini C, Corti C, Bernardi M, Ciceri F, Peccatori J. Posttransplantation Cyclophosphamide- and Sirolimus-Based Graft-Versus-Host-Disease Prophylaxis in Allogeneic Stem Cell Transplant. Transplant Cell Ther 2021 09; 27: 776.e1-776.e13. doi: 10.1016/j.jtct.2021.05.023.

Fedeli M, Kuka M, Finardi A, Albano F, Viganò V, Iannacone M, Furlan R, Dellabona P, Casorati G. miR-21 sustains CD28 signalling and low-affinity T-cell responses at the expense of self-tolerance. Clin Transl Immunology. 2021 Sep 21;10(9):e1321. doi: 10.1002/cti2.1321.

Conforti A, Marra E, Palombo F, Roscilli G, Ravà M, Fumagalli V, Muzi A, Maffei M, Luberto L, Lione L, Salvatori E, Compagnone M, Pinto E, Pavoni E, Bucci F, Vitagliano G, Stoppoloni D, Pacello ML, Cappelletti M, Ferrara FF, D'Acunto E, Chiarini V, Arriga R, Nyska A, Di Lucia P, Marotta D, Bono E, Giustini L, Sala E, Perucchini C, Paterson J, Ryan KA, Challis AR, Matusali G, Colavita F, Caselli G, Criscuolo E, Clementi N, Mancini N, Groß R, Seidel A, Wettstein L, Münch J, Donnici L, Conti M, De Francesco R, Kuka M, Ciliberto G, Castilletti C, Capobianchi MR, Ippolito G, Guidotti LG, Rovati L, Iannacone M, Aurisicchio L. COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal models. Mol Ther. 2021 Sep 20:S1525-0016(21)00466-4. doi: 10.1016/j.ymthe.2021.09.011.

De Simone G, Andreata F, Bleriot C, Fumagalli V, Laura C, Garcia-Manteiga JM, Di Lucia P, Gilotto S, Ficht X, De Ponti FF, Bono EB, Giustini L, Ambrosi G, Mainetti M, Zordan P, Bénéchet AP, Ravà M, Chakarov S, Moalli F, Bajenoff M, Guidotti LG, Ginhoux F, Iannacone M. Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming. Immunity. 2021 Sep 14;54(9):2089-2100.e8. doi: 10.1016/j.immuni.2021.05.005.

Ferrara B, Pignatelli C, Cossutta M, Citro A, Courtyì J, Piemonti L. The Extracellular Matrix in Pancreatic Cancer: Description of a Complex Network and Promising Therapeutic Options. Cancers (Basel). 2021 Sep 3;13(17):4442. doi: 10.3390/cancers13174442.

Grioni M, Brevi A, Cattaneo E, Rovida A, Bordini J, Bertilaccio MTS, Ponzoni M, Casorati G, Dellabona P, Ghia P, Bellone M,Calcinotto A. CD4+ T cells sustain aggressive chronic lymphocytic leukemia in Eμ-TCL1 mice through a CD40L-independent mechanism. Blood Adv 2021 07; 5: 2817-2828. doi: 10.1182/bloodadvances.2020003795.

Ratti F, Casadei-Gardini A, Cipriani F, Fiorentini G, Pedica F, Burgio V, Cascinu S, Aldrighetti L. Laparoscopic Surgery for Intrahepatic Cholangiocarcinoma: A Focus on Oncological Outcomes. J Clin Med. 2021 Jun 26;10(13):2828. doi: 10.3390/jcm10132828.

Cilenti F*, Barbiera G*, Caronni N, Iodice D, Montaldo E, Barresi E, Lusito E, Cuzzola V, Vittoria FM, Mezzanzanica L, Miotto P, Di Lucia P, Lazarevic D, Cirillo DM, Iannacone M, Genua M^, Ostuni R^. A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression. IMMUNITY. 2021 June 14. doi:10.1016/j.immuni.2021.05.01. (*= equal contribution ^=equal contribution)

Manfredi F, Abbati D, Cianciotti BC, Stasi L, Potenza A, Ruggiero E, Magnani Z, Carnevale E, Doglio M, Noviello M, Tassi E, Balestrieri C, Buonanno S, Clemente F, De Lalla C, Protti MP, Mondino A, Casorati G, Dellabona P, Bonini C. Flow cytometry data mining by cytoChain identifies determinants of exhaustion and stemness in TCR-engineered T cells. Eur J Immunol. 2021 Jun 3. doi: 10.1002/eji.202049103.

Sacchi A, Gasparri AM, Monieri M, Anderluzzi G , Colombo B , Gori A, Corti A* and Curnis F*. Nanogold functionalized with lipoamide-isoDGR: a simple, robust and versatile nanosystem for avb3-integrin targeting Front Chem. 2021 May 28;9:690357. doi: 10.3389/fchem.2021.690357. (* Co-Corresponding Author)

Talamini L, Picchetti P, Ferreira LM, Sitia G, Russo L, Violatto MB, Travaglini L, Fernandez Alarcon J, Righelli L, Bigini P and De Cola L. Organosilica Cages Target Hepatic Sinusoidal Endothelial Cells Avoiding Macrophage Filtering.  ACS Nano. 2021 May 19. doi:10.1021/acsnano.1c00316.

Iannacone M, Guidotti LG. Immunobiology and pathogenesis of hepatitis B virus infection. Nat Rev Immunol. 2021 May 17. doi: 10.1038/s41577-021-00549-4.

Corti A*, Sacchi A, Gasparri AM, Monieri M , Anderluzzi G, Colombo B, Gori A, Mondino A and Curnis F*. Enhancement of doxorubicin anti-cancer activity by vascular targeting using IsoDGR/cytokine-coated nanogold. J Nanobiotechnology. 2021 May 5;19(1):128. doi:10.1186/s12951-021-00871-y. (* Co-Corresponding Author)

Exley MA, Dellabona P, Casorati G. Exploiting CD1-restricted T cells for clinical benefit. MOL IMMUNOL 2021 Feb; 132: 126-131. doi: 10.1016/j.molimm.2020.12.015.

Ratti F, Cipriani F, Fiorentini G, Burgio V, Ronzoni M, Della Corte A, Cascinu S, De Cobelli F, and Aldrighetti L. Evolution of surgical treatment of Colorectal Liver Metastases 2in the real world: single center experience in 1212 cases. CANCERS 2021 Mar 9;13(5):1178. doi: 10.3390/cancers13051178.

Caronni N, Montaldo E, Mezzanzanica L, Cilenti F, Genua M, Ostuni R. Determinants, mechanisms, and outcomes of myeloid cell diversity in cancer. IMMUNOL REV 2021 Feb 9. doi: 10.1111/imr.12944.

Maspes A, Pizzetti F, Rossetti A, Makvandi P, Sitia G, Rossi F. Advances in Bio-Based Polymers for Colorectal CancerTreatment: Hydrogels and Nanoplatforms. Gels. 2021 Jan 11;7(1):6. doi: 10.3390/gels7010006.

Reni M, Andreasi V , Gasparri AM , Dugnani E , Colombo B, Macchini M, Bianco M, Dallatomasina A, Citro A, Assi  E, Protti MP, Esposito A, Falconi M, Curnis F, Piemonti L, and Corti A. Circulating chromogranin A is cleaved into vasoregulatory fragments in patients with pancreatic ductal adenocarcinoma. Front Oncol. 2020 Dec 23;10:613582. doi: 10.3389/fonc.2020.613582.

Fumagalli V, Di Lucia P, Venzin V, Bono EB, Jordan R, Frey CR, Delaney W, Chisari FV, Guidotti LG†, Iannacone M†. Serum HBsAg clearance has minimal impact on CD8+ T cell responses in mouse models of HBV infection. J Exp Med. 2020 Nov 2;217(11):e20200298. doi: 10.1084/jem.20200298. (†Co-Last Authors)

Corti A, Gasparri AM, Sacchi A, Colombo B, Monieri M, Rrapaj E, Ferreri AJM, Curnis F. NGR-TNF Engineering with an N-Terminal Serine Reduces Degradation and Post-Translational Modifications and Improves Its Tumor-Targeting Activity. Mol Pharm. 2020 Oct 5;17(10):3813-3824. doi: 10.1021/acs.molpharmaceut.0c00579.

Protti MP, De Monte L. Thymic stromal lymphopoietin and Cancer: Th2-dependent and -independent mechanisms. Front Immunol. 2020 Sep 16;11:2088. doi: 10.3389/fimmu.2020.02088.

Ficht X, Iannacone M. Immune surveillance of the liver by T cells. Sci Immunol. 2020 Sep 4;5(51):eaba2351. doi: 10.1126/sciimmunol.aba2351.

Manfredi F, Cianciotti BC, Potenza A, Tassi E, Noviello E, Biondi A, Ciceri F, Bonini C*, Ruggiero E.* TCR redirected T cells for cancer treatment: Acheivements, hurdles and goals. Front Immunol. 2020 Sep 3;11:1689. doi: 10.3389/fimmu.2020.01689. (*= equal contribution)

McGrath E, Chabannon C, Terwel S, Bonini C, Kuball J. Opportunities and challenges associated with the evaluation of chimeric antigen receptor T cells in real-life. Current Opinion in Oncology: Sep 2020 - Volume 32 - Issue 5 - p 427-433 doi: 10.1097/CCO.0000000000000665.

Arcangeli S*, Mestermann K*, Weber J*, Bonini C^, Casucci M^, Michael M.^ Overcoming key challenges in engineered T cell cancer immunotherapy. Current Opinion in Oncology. 2020 Sep;32(5):398-407. doi: 10.1097/CCO.0000000000000664. (*= equal contribution ^=equal contribution).

De Giovanni M, Cutillo V, Giladi A, Sala E, Maganuco CG, Medaglia C, Di Lucia P, Bono E, Cristofani C, Consolo E, Giustini L, Fiore A, Eickhoff S, Kastenmüller W, Amit I, Kuka M, Iannacone M. Spatiotemporal regulation of type I interferon expression determines the antiviral polarization of CD4+ T cells. NAT IMMUNOL 2020 Mar; 21: 321-330. doi: 10.1038/s41590-020-0596-6.

Protti, MP and De Monte L. Dual Role of Inflammasome Adaptor ASC in Cancer.Front Cell Dev Bio 2020 Feb; 8: Article 40. doi: 10.3389/fcell.2020.00040.

Nardelli F, Ghitti M, Quilici G, Gori A, Luo Q, Berardi A, Sacchi A, Monieri M, Bergamaschi G, Bermel W, Chen F, Corti A, Curnis F, Musco G. A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8. CHEM COMMUN 2019 Dec; 55: 14777-14780. doi: 10.1039/c9cc08518a.

Mahata SK, Corti A. Chromogranin A and its fragments in cardiovascular, immunometabolic, and cancer regulation. ANN NY ACAD SCI 2019 Nov; 1455: 34-58. doi: 10.1111/nyas.14249.

Gasparri AM, Sacchi A, Basso V, Cortesi F, Freschi M, Rrapaj E, Bellone M, Casorati G, Dellabona P, Mondino A, Corti A, Curnis F. Boosting Interleukin-12 Antitumor Activity and Synergism with Immunotherapy by Targeted Delivery with isoDGR-Tagged Nanogold. SMALL 2019 Nov; 15: e1903462. doi: 10.1002/smll.201903462.

Comoli P, Chabannon C, Koehl U, Lanza F, Urbano-Ispizua A, Hudecek M, Ruggeri A, Secondino S, Bonini C, Pedrazzoli P. Development of adaptive immune effector therapies in solid tumors. Ann Oncol. 2019 Nov 1;30(11):1740-1750. doi: 10.1093/annonc/mdz285.

Bénéchet AP, De Simone G, Di Lucia P, Cilenti F, Barbiera G, Le Bert N, Fumagalli V, Lusito E, Moalli F, Bianchessi V, Andreata F, Zordan P, Bono E, Giustini L, Bonilla WV, Bleriot C, Kunasegaran K, Gonzalez-Aseguinolaza G, Pinschewer DD, Kennedy PTF, Naldini L, Kuka M, Ginhoux F, Cantore A, Bertoletti A, Ostuni R, Guidotti LG, Iannacone M. Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming. Nature. 2019 Oct;574(7777):200-205. doi: 10.1038/s41586-019-1620-6.

Total Publications: 75
Total IF: 1327.564
Mean IF: 18.186 
Last update: 01/02/2024